Evidence map›Paper›PMID 27156998›Full record

ArticleScientific reports2016

Urinary arsenic profiles reveal exposures to inorganic arsenic from private drinking water supplies in Cornwall, UK.

D R S Middleton, M J Watts, E M Hamilton, E L Ander, R M Close, K S Exley, H Crabbe, G S Leonardi, T Fletcher, D A Polya

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
  4. Article
  5. Review
  6. Chronic dietary exposure to inorganic arsenic.EFSA journal. European Food Safety Authority · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Remarks on the current quality of groundwater in Vietnam.Environmental science and pollution research international · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

D R S MiddletonSchool of Earth, Atmospheric and Environmental Sciences &Williamson Research Centre for Molecular Environmental Science, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
M J WattsInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, Nicker Hill, Keyworth, Nottinghamshire, NG12 5GG, UK.
E M HamiltonInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, Nicker Hill, Keyworth, Nottinghamshire, NG12 5GG, UK.
E L AnderInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, Nicker Hill, Keyworth, Nottinghamshire, NG12 5GG, UK.
R M CloseCentre for Radiation, Chemicals and Environmental Hazards (CRCE), Public Health England, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
K S ExleyCentre for Radiation, Chemicals and Environmental Hazards (CRCE), Public Health England, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
H CrabbeCentre for Radiation, Chemicals and Environmental Hazards (CRCE), Public Health England, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
G S LeonardiCentre for Radiation, Chemicals and Environmental Hazards (CRCE), Public Health England, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
T FletcherCentre for Radiation, Chemicals and Environmental Hazards (CRCE), Public Health England, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
D A PolyaSchool of Earth, Atmospheric and Environmental Sciences &Williamson Research Centre for Molecular Environmental Science, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
Public Health England · GBBritish Geological Survey · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Private water supplies (PWS) in Cornwall, South West England exceeded the current WHO guidance value and UK prescribed concentration or value (PCV) for arsenic of 10 μg/L in 5% of properties surveyed (n = 497). In this follow-up study, the first of its kind in the UK, volunteers (n = 207) from 127 households who used their PWS for drinking, provided urine and drinking water samples for total As determination by inductively coupled plasma mass spectrometry (ICP-MS) and urinary As speciation by high performance liquid chromatography ICP-MS (HPLC-ICP-MS). Arsenic concentrations exceeding 10 μg/L were found in the PWS of 10% of the volunteers. Unadjusted total urinary As concentrations were poorly correlated (Spearman's ρ = 0.36 (P < 0.001)) with PWS As largely due to the use of spot urine samples and the dominance of arsenobetaine (AB) from seafood sources. However, the osmolality adjusted sum, U-As(IMM), of urinary inorganic As species, arsenite (As(III)) and arsenate (As(V)), and their metabolites, methylarsonate (MA) and dimethylarsinate (DMA), was found to strongly correlate (Spearman's ρ: 0.62 (P < 0.001)) with PWS As, indicating private water supplies as the dominant source of inorganic As exposure in the study population of PWS users.

Indexed as

Water SupplyAdolescentAdultAgedAged, 80 and overArsenicDemographyDrinking WaterEnvironmental ExposureFamily CharacteristicsFemaleGeographyHumansMaleMiddle AgedUnited KingdomArsenicDrinking Water

Identifiers

PMID27156998
PMCPMC4860641
OpenAlexW2346534394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.