Evidence map›Paper›PMID 27156926›Full record

ArticleAutism research : official journal of the International Society for Autism Research2017

Atypical rapid audio-visual temporal recalibration in autism spectrum disorders.

Jean-Paul Noel, Matthew A De Niear, Ryan Stevenson, David Alais, Mark T Wallace

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06872229 (How the Simultaneous or Delayed Presentation of Visual and Auditory Stimuli Affects Response Accuracy and Reaction Times in Participants With Autism Spectrum Condition), which is not on this map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06872229 recruitingnot on this mapstarted 2025, after this paper: background citation

How the Simultaneous or Delayed Presentation of Visual and Auditory Stimuli Affects Response Accuracy and Reaction Times in Participants With Autism Spectrum Condition (ASC) During an Association Task.

TypeobservationalSponsorIstituto per la Ricerca e l'Innovazione BiomedicaRan2025 to 2027Enrolled100ConditionsAutism, Autism Spectrum DisorderArmsAutism Spectum Conditions - intervention, Typical Development - intervention
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
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  4. Time perception and autistic spectrum condition: A systematic review.Autism research : official journal of the International Society for Autism Research · 2019
    Pooled it
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  20. Multisensory integration in the mammalian brain: diversity and flexibility in health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Jean-Paul NoelNeuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University Medical School, Vanderbilt University, Nashville, Tennessee.
Matthew A De NiearVanderbilt Brain Institute, Vanderbilt University Medical School, Vanderbilt University, Nashville, Tennessee.
Ryan StevensonVanderbilt Brain Institute, Vanderbilt University Medical School, Vanderbilt University, Nashville, Tennessee.
David AlaisSchool of Psychology, University of Sydney, Sydney, Australia.
Mark T WallaceVanderbilt Brain Institute, Vanderbilt University Medical School, Vanderbilt University, Nashville, Tennessee.
Vanderbilt Health · USVanderbilt University · USUniversity of Sydney · AU

Funding

Training in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALLACE, MARK THOMAS · 2015 to 2019
$7.1M
Multisensory Integration and Temporal processing in AutismF32DC011993 · NIDCD · VANDERBILT UNIVERSITY · PI STEVENSON, RYAN ANDREW · 2011 to 2013
$92k
Spatial, Temporal, and Spatio-Temporal Multisensory Binding Windows in Autism Spectrum DisorderF31MH112336 · NIMH · VANDERBILT UNIVERSITY · PI NOEL, JEAN-PAUL · 2017 to 2019
$32k
NICHD NIH HHS U54 HD083211NIDCD NIH HHS F32 DC011993NIMH NIH HHS F31 MH112336NIMH NIH HHS T32 MH064913
6 · The paper itself

Abstract

Changes in sensory and multisensory function are increasingly recognized as a common phenotypic characteristic of Autism Spectrum Disorders (ASD). Furthermore, much recent evidence suggests that sensory disturbances likely play an important role in contributing to social communication weaknesses-one of the core diagnostic features of ASD. An established sensory disturbance observed in ASD is reduced audiovisual temporal acuity. In the current study, we substantially extend these explorations of multisensory temporal function within the framework that an inability to rapidly recalibrate to changes in audiovisual temporal relations may play an important and under-recognized role in ASD. In the paradigm, we present ASD and typically developing (TD) children and adolescents with asynchronous audiovisual stimuli of varying levels of complexity and ask them to perform a simultaneity judgment (SJ). In the critical analysis, we test audiovisual temporal processing on trial t as a condition of trial t - 1. The results demonstrate that individuals with ASD fail to rapidly recalibrate to audiovisual asynchronies in an equivalent manner to their TD counterparts for simple and non-linguistic stimuli (i.e., flashes and beeps, hand-held tools), but exhibit comparable rapid recalibration for speech stimuli. These results are discussed in terms of prior work showing a speech-specific deficit in audiovisual temporal function in ASD, and in light of current theories of autism focusing on sensory noise and stability of perceptual representations. Autism Res 2017, 10: 121-129. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Indexed as

Acoustic StimulationAdolescentAuditory PerceptionAutism Spectrum DisorderChildFemaleHumansJudgmentMalePhotic StimulationTime PerceptionVisual Perceptionaudio-visualautismmultisensoryplasticityrecalibration

Identifiers

PMID27156926
PMCPMC10791168
OpenAlexW2387891818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.