SynthesisAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2016
Immune-mediated reactions to vancomycin: A systematic case review and analysis.
Synthesis in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fatal outcome related to drug reaction with eosinophilia and systemic symptoms: a disproportionality analysis of FAERS database and a systematic review of cases.Frontiers in immunology · 2024Pooled it
- Vancomycin therapeutic drug monitoring is associated with reduced toxicity in ICU patients: a MIMIC-IV retrospective study.Scientific reports · 2026Article
- Drug Reaction with Eosinophilia and Systemic Symptoms in the Electronic Medical Record.International archives of allergy and immunology · 2026Article
- Vicious Vanco: Vancomycin-Induced Cutaneous Small-Vessel Vasculitis in a Patient With End-Stage Renal Disease.Cureus · 2026Article
- The additive effect of IgE-mediated and pseudoallergic hypersensitivity in RBL-2H3 cells and guinea pigs.PloS one · 2026Article
- Afebrile vancomycin-induced delayed hypersensitivity suggestive of incomplete drug rash with eosinophilia and systemic symptoms syndrome: a case report.Journal of medical case reports · 2025Article
- Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug-Specific Activation Responses In Vitro.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Quaternized chitosan derivatives inhibit growth and affect biofilm formation of Staphylococcus aureus.Scientific reports · 2025Article
- Article
- A Skin Testing Strategy for Non-IgE-Mediated Reactions Associated With Vancomycin.The journal of allergy and clinical immunology. In practice · 2024Article
- Intestinal dysbiosis as an intraoperative predictor of septic complications: evidence from human surgical cohorts and preclinical models of peritoneal sepsis.Scientific reports · 2023Article
- Ethics of antibiotic allergy.Journal of medical ethics · 2023Article
- Experimental Evaluation of the Hypersensitivity Reactions of a New Glycopeptide Antibiotic Flavancin in Animal Models.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- Vancomycin-Induced Leukocytoclastic Vasculitis: A Rare Complication From a Commonly Used Medication.Cureus · 2023Article
- Outcome of preoperative cefazolin use for infection prophylaxis in patients with self-reported penicillin allergy.BMC surgery · 2023Article
- A rare case of infant eosinophilia induced by oral vancomycin: a case report and literature review.The Journal of international medical research · 2023Review
- Vancomycin- and piperacillin-induced acute interstitial nephritis in a patient with lupus: A case report showcasing rapid decline in renal function.Clinical nephrology. Case studies · 2023Article
- Dermatosis Neglecta Based on Exanthematous Drug Eruption Following Head Trauma: A Case Report and Literature Review.Clinical, cosmetic and investigational dermatology · 2023Article
- Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides.Clinical reviews in allergy & immunology · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundVancomycin is a broad-spectrum antibiotic whose use may be limited by adverse drug reactions (ADRs). Although vancomycin toxic effects are known, there are limited data on vancomycin hypersensitivity reactions (HSRs).
objectiveTo understand the most commonly reported vancomycin HSRs through systematic case review.
methodsWe performed a literature search for English-language case reports and series from 1982 through 2015 (last search July 31, 2015) on Ovid MEDLINE and PubMed. The search included the subject heading vancomycin with the subheading adverse effects and separate text searches for vancomycin with a list of specified HSRs. References of identified articles were reviewed to find additional articles. Clinical data were collected and summarized.
resultsOf 201 identified articles, 84 were screened and 57 fully assessed; these 57 articles contained 71 vancomycin HSR cases that were included in analysis. Vancomycin HSRs were immediate (anaphylaxis, n = 7) and nonimmediate (n = 64). Nonimmediate HSRs included linear IgA bullous dermatosis (LABD, n = 34), drug rash eosinophilia and systemic symptoms (DRESS) syndrome (n = 16), acute interstitial nephritis (AIN, n = 8), and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN, n = 6). Median times of vancomycin therapy before HSR onset was 7 days (interquartile range [IQR], 4-10 days) for LABD, 9 days (IQR, 9-22 days) for SJS/TEN, 21 days (IQR, 17-28 days) for DRESS syndrome, and 26 days (IQR, 7-29 days) for AIN. Overall, 11 patients (16%) died, and 4 (6%) had deaths attributed to the HSR.
conclusionVancomycin causes a variety of HSRs; the most commonly identified were nonimmediate HSRs, with LABD being most frequent. We observed a high frequency of HSR mortality. Further data are needed to understand the frequency and severity of vancomycin HSRs.
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