ArticleRedox biology2016
The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose.
Article in Redox biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Thiol-catalyzed formation of NO-ferroheme regulates intravascular NO signaling.Nature chemical biology · 2023Article
- Thiol catalyzed formation of NO-ferroheme regulates canonical intravascular NO signaling.Research square · 2023Article
- Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-In Mouse.Antioxidants & redox signaling · 2021Review
- Effects of nitrite and far-red light on coagulation.Nitric oxide : biology and chemistry · 2021Article
- Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.Circulation research · 2020Review
- Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.Circulation · 2019Article
- Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation.Journal of visualized experiments : JoVE · 2019Article
- Nitrite and nitrate chemical biology and signalling.British journal of pharmacology · 2019Review
- Erythrocytic bioactivation of nitrite and its potentiation by far-red light.Redox biology · 2019Article
- Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.Frontiers in physiology · 2018Review
- Article
- Potential therapeutic action of nitrite in sickle cell disease.Redox biology · 2017Article
- Recent insights into nitrite signaling processes in blood.Biological chemistry · 2017Article
- Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis.Cell communication and signaling : CCS · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Previous work has shown that red blood cells (RBCs) reduce nitrite to NO under conditions of low oxygen. Strong support for the ability of red blood cells to promote nitrite bioactivation comes from using platelet activation as a NO-sensitive process. Whereas addition of nitrite to platelet rich plasma in the absence of RBCs has no effect on inhibition of platelet activation, when RBCs are present platelet activation is inhibited by an NO-dependent mechanism that is potentiated under hypoxia. In this paper, we demonstrate that nitrite bioactivation by RBCs is blunted by physiologically-relevant concentrations of nutrients including glucose and the important signaling amino acid leucine. Our mechanistic investigations demonstrate that RBC mediated nitrite bioactivation is largely dependent on nitrosation of RBC surface proteins. These data suggest a new expanded paradigm where RBC mediated nitrite bioactivation not only directs blood flow to areas of low oxygen but also to areas of low nutrients. Our findings could have profound implications for normal physiology as well as pathophysiology in a variety of diseases including diabetes, sickle cell disease, and arteriosclerosis.
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Registered trials
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