Evidence map›Paper›PMID 27155846›Full record

Trial reportEuropean journal of applied physiology2016

Electrical stimulation and blood flow restriction increase wrist extensor cross-sectional area and flow meditated dilatation following spinal cord injury.

Ashraf S Gorgey, Mark K Timmons, David R Dolbow, Justin Bengel, Kendall C Fugate-Laus, Lori A Michener, David R Gater

2 registry-linked trialsAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03690700 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Feasibility and Effects of Low-load Blood-flow Restricted Exercise Following Spinal Cord Injury

TypeinterventionalSponsorSpinal Cord Injury Centre of Western DenmarkRan2020 to 2024Enrolled28ConditionsSpinal Cord InjuriesArmsBFRE
NCT07782723 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effects Of Combining Blood Flow Restriction Therapy With Extracorporeal Shock Wave Therapy On Pain, Muscle Strength, And Functional Outcomes İn Patients Diagnosed With Lateral Epicondylitis: a Randomized Controlled Trial

TypeinterventionalSponsorAnkara Yildirim Beyazıt UniversityRan2025 to 2027Enrolled52ConditionsLateral EpicondylitisArmsBlood Flow Restriction Therapy, Extracorporeal Shock Wave Therapy
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Effects of functional electro-stimulation combined with blood flow restriction in affected muscles by spinal cord injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Ashraf S GorgeyDepartment of Veterans Affairs, Hunter Holmes McGuire VA Medical Center, Spinal Cord Injury and Disorders Service, 1201 Broad Rock Boulevard, Richmond, VA, 23249, USA. ashraf.gorgey@va.gov.
Mark K TimmonsSchool of Kinesiology, Marshall University, Huntington, WV, USA.
David R DolbowSchool of Kinesiology, College of Health, University of Southern Mississippi, Hattiesburg, MS, USA.
Justin BengelDepartment of Veterans Affairs, Hunter Holmes McGuire VA Medical Center, Spinal Cord Injury and Disorders Service, 1201 Broad Rock Boulevard, Richmond, VA, 23249, USA.
Kendall C Fugate-LausDepartment of Veterans Affairs, Hunter Holmes McGuire VA Medical Center, Spinal Cord Injury and Disorders Service, 1201 Broad Rock Boulevard, Richmond, VA, 23249, USA.
Lori A MichenerDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.
David R GaterDepartment of Physical Medicine and Rehabilitation, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
Marshall University · USPenn State Milton S. Hershey Medical Center · USUniversity of Southern California · USUniversity of Southern Mississippi · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the effects of neuromuscular electrical stimulation (NMES) and blood flow restricted (BFR) exercise on wrist extensors cross-sectional area (CSA), torque and hand functions compared NMES only in individuals with incomplete tetraplegia. The acute effect of an acute bout of NMES with BFR on flow mediated dilation (FMD) was compared with BFR only.

methodNine men completed 6 weeks twice weekly of bilateral NMES training of the wrist extensor muscles. The right forearm received NMES + BFR (30 % above the resting systolic blood pressure), while the left forearm received NMES only. The CSA of the extensor carpi radialis longus (ECRL) and extensor digitorum communis (EDC) muscles was measured on ultrasound images. Torque was measured isometrically and hand function with grasp and release test. Another eight men with SCI received NMES+BFR to the right forearm, while the left forearm received BFR only. Immediately, the FMD of the brachial artery was measured.

resultFollowing training, the ECRL CSA was 17 % greater in the NMES+BFR forearm (mean difference = 0.6 cm(2), p = 0.003) compared with the NMES only. The NMES+BFR had a 15 % increase in ECRL CSA (mean increase = 0.58 cm(2), p = 0.048). FMD increased (p = 0.05) in the exercise arm (12 ± 3 %) compared with the control arm (6.5 ± 6 %).

conclusionNMES training with BFR is a strategy that can increase skeletal muscle size. NMES with and without BFR can improve wrist strength and hand function. The acute effects of NMES+BFR may suggest that an increase in FMD may partially contribute to skeletal muscle hypertrophy.

Indexed as

Muscle StrengthBlood Flow VelocityCombined Modality TherapyElectric Stimulation TherapyHumansMaleMiddle AgedMuscle, SkeletalMuscular AtrophyResistance TrainingSpinal Cord InjuriesTreatment OutcomeWrist JointBlood flow restrictionNMESRehabilitationSpinal cord injuryTraining

Identifiers

PMID27155846
OpenAlexW2347092943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.