Evidence map›Paper›PMID 27155784›Full record

ArticleAlcoholism, clinical and experimental research2016

Associations Between Gestational Age at Birth and Alcohol Use in the Avon Longitudinal Study of Parents and Children.

Elizabeth K Do, Shawn J Latendresse, Alexis C Edwards, Kenneth S Kendler, Danielle M Dick, Timothy P York

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elizabeth K DoDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0003-3503-1731
Shawn J LatendresseDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas.
Alexis C EdwardsDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Kenneth S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Danielle M DickDepartments of Psychology, African American Studies, and Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.
Timothy P YorkDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Virginia Commonwealth University · USBaylor University · US

Funding

VCU NIMHD Comprehensive Center of Excellence (Project 1; PI: Strauss)P60MD002256 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI CONEY, PONJOLA · 2007 to 2016
$13.1M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Research Education in Statistical Genetics of Substance AbuseR25DA026119 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2008 to 2018
$3.2M
Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyR01AA018333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M, KENDLER, KENNETH SEEDMAN · 2010 to 2014
$2.8M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Phenotypic refinement of externalizing pathways to alcohol-related behaviorsK01AA020333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI LATENDRESSE, SHAWN J. · 2011 to 2015
$812k
Genetic influences on developmental heterogeneity of alcohol use disorderK01AA021399 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EDWARDS, ALEXIS C · 2012 to 2016
$707k
Medical Research Council G9815508Medical Research Council MC_PC_15018NCATS NIH HHS UL1 TR000058NIAAA NIH HHS K01 AA020333NIAAA NIH HHS K01 AA021399NIAAA NIH HHS K02 AA018755NIAAA NIH HHS R01 AA018333NIDA NIH HHS R25 DA026119NIMHD NIH HHS P60 MD002256Wellcome TrustWellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

backgroundThe relationship between gestational age at birth (GA) and alcohol use measures in early adulthood was examined in a large U.K. community-based birth cohort (Avon Longitudinal Study of Parents and Children).

methodsA series of linear and logistic regression models were used to test for main effects of a continuous measure of GA on a range of alcohol use measures, and moderation of these associations by sex. In addition, mediation analyses assessed the extent to which significant associations between GA and alcohol use operated indirectly, through influences of the parental environment and/or childhood measures of emotional and behavioral health (EBH).

resultsEarlier GA significantly predicted never drinking by age 18, but was not associated with other measures of alcohol use behavior among young adult drinkers (i.e., Self-Rating of the Effects of Alcohol, Alcohol Use Disorders Identification Test, or DSM-IV-TR Criteria for Alcohol Dependence). The association between earlier GA and never drinking by age 18 was moderated by sex, such that females born early were less likely to have ever had a drink by age 18. In the full sample, childhood measures of EBH were found to mediate the association between earlier GA and never drinking by age 18. This association was not mediated by parenting factors.

conclusionsEarlier GA is associated with never drinking alcohol in early adulthood, in females. Emotional and behavioral difficulties experienced in early childhood may mediate the relationship between earlier GA and never drinking by age 18.

Indexed as

Gestational AgeAdolescentAdultAffective SymptomsAge FactorsAlcohol DrinkingFemaleHumansLongitudinal StudiesMaleProblem BehaviorSex FactorsUnited KingdomYoung AdultAlcohol DependenceAvon Longitudinal Study of Parents and ChildrenEmotional and Behavioral DifficultiesGestational Age at BirthParental Environment

Identifiers

PMID27155784
PMCPMC4889493
OpenAlexW2346344995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.