ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2016
Ethnic Variations in Duodenal Villous Atrophy Consistent With Celiac Disease in the United States.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease.PloS one · 2021Pooled it
- Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis.The American journal of gastroenterology · 2017Pooled it
- Non-Celiac Villous Atrophy-A Problem Still Underestimated.Life (Basel, Switzerland) · 2025Review
- Predictors of Subsequent Celiac Disease Seropositivity in Patients Diagnosed with Duodenal Villus Atrophy on Upper Endoscopy.Digestive diseases and sciences · 2024Article
- Villous Atrophy: Flat Mucosa, Raised Questions.Digestive diseases and sciences · 2024Article
- Celiac disease symptom profiles and their relationship to gluten-free diet adherence, mental health, and quality of life.BMC gastroenterology · 2024Observational
- Psychometric validation of the celiac disease-specific quality of life survey (CD-QOL) in adults with celiac disease in the United States.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Important denominator between autoimmune comorbidities: a review of class II HLA, autoimmune disease, and the gut.Frontiers in immunology · 2023Review
- Celiac Disease: Fallacies and Facts.The American journal of gastroenterology · 2021Review
- Bedouin Children With Celiac Disease: Less Symptoms but More Severe Histological Features at Presentation.Frontiers in pediatrics · 2020Article
- Frequency of HLA celiac disease risk alleles and haplotypes in healthy adults in Tamil Nadu.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence.Medicina (Kaunas, Lithuania) · 2019Review
- Celiac disease in Iranian irritable bowel syndrome patients; a systematic review and meta-analysis.Gastroenterology and hepatology from bed to bench · 2019Review
- Interaction of Ethnicity and H. pylori Infection in the Occurrence of Microscopic Colitis.Digestive diseases and sciences · 2017Article
- Prevalence and Predictors of Giardia in the United States.Digestive diseases and sciences · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsCeliac disease is a common disorder with a worldwide distribution, although the prevalence among different ethnicities varies. We aimed to measure the prevalence of duodenal villous atrophy among patients of different ethnicities throughout the United States.
methodsWe performed a cross-sectional study of all patients who had duodenal biopsies submitted to a national pathology laboratory between January 2, 2008 and April 30, 2015. The prevalence of villous atrophy was calculated for the following ethnicities by using a previously published algorithm based on patient names: North Indian, South Indian, East Asian, Hispanic, Middle Eastern, Jewish, and other Americans.
resultsAmong all patients (n = 454,885), the median age was 53 years, and 66% were female. The overall prevalence of celiac disease was 1.74%. Compared with other Americans (n = 380,163; celiac disease prevalence, 1.83%), celiac disease prevalence was lower in patients of South Indian (n = 177, 0%; P = .08), East Asian (n = 4700, 0.15%; P ≤ .0001), and Hispanic (n = 31,491, 1.06%; P ≤ .0001) ethnicities. Celiac disease was more common in patients from the Punjab region (n = 617, 3.08%) than in patients from North India (n = 1195, 1.51%; P = .02). The prevalence of celiac disease among patients of Jewish (n = 17,806, 1.80%; P = .78) and Middle Eastern (n = 1903, 1.52%; P = .33) ethnicities was similar to that of other Americans. Among Jewish individuals (n = 17,806), the prevalence of celiac disease was 1.83% in Ashkenazi persons (n = 16,440) and 1.39% in Sephardic persons (n = 1366; P = .24).
conclusionsAmong patients undergoing duodenal biopsy, individuals from the Punjab region of India constitute the ethnic group in the United States with the highest prevalence of villous atrophy consistent with celiac disease. Compared with other Americans, villous atrophy prevalence on duodenal biopsy is significantly lower among U.S. residents of South Indian, East Asian, and Hispanic ancestry.
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