Evidence map›Paper›PMID 27155552›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2016

Cumulative Length of Bowel Resection in a Population-Based Cohort of Patients With Crohn's Disease.

Laurent Peyrin-Biroulet, W Scott Harmsen, William J Tremaine, Alan R Zinsmeister, William J Sandborn, Edward V Loftus

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. ACG Clinical Guideline: Management of Crohn's Disease in Adults.The American journal of gastroenterology · 2018
    Guideline
  2. Article
  3. Article
  4. Challenges in IBD Research 2024: Novel Technologies.Inflammatory bowel diseases · 2024
    Review
  5. Article
  6. Observational
  7. Review
  8. Review
  9. Surgical management of Crohn's disease: a state of the art review.International journal of colorectal disease · 2021
    Review
  10. Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Laurent Peyrin-BirouletDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Hepato-Gastroenterology, University Hospital of Nancy, Henri Poincare University, Vandoeuvre-les-Nancy, France.
W Scott HarmsenDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
William J TremaineDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Alan R ZinsmeisterDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
William J SandbornDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology, University of California San Diego, La Jolla, California.
Edward V LoftusDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: loftus.edward@mayo.edu.
Mayo Clinic · US

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

BACKGROUND &

aimsLittle is known about the cumulative extent of bowel resection among patients with Crohn's disease.

methodsUsing the resources of the Rochester Epidemiology Project, we identified a cohort of 310 incident cases of Crohn's disease from Olmsted County, Minnesota who were diagnosed between 1970 and 2004. Operative and pathology reports were reviewed for bowel resection length. Median bowel resection lengths (with interquartile range [IQR]) were calculated per resection, cumulatively, and as a rate per year of follow-up.

resultsOne hundred forty-seven patients underwent 1 or more bowel resections. The median follow-up time per patient was 13.6 years (range, 0.2-39 years). Among the 141 patients with resection data available, 211 resections were performed (100 patients with 1 resection, 24 with 2 resections, 9 with 3 resections, 6 with 4 resections, 1 with 5 resections, and 1 patient with 7 resections). The median length of bowel resected was 40 cm (IQR, 22-65 cm) at any resection. The median cumulative length of bowel resected was 64 cm (38-93 cm) during the follow-up period. The median (IQR) rate of bowel resected was 4.2 cm total bowel annually (2.8-7.7 cm). The median length resected was highest for the first resection (52 cm; IQR, 32-71 cm). A mixed regression analysis showed that the length of the first resection was significantly greater than that of the second (P = .002), without significant differences between the second and third or subsequent resections.

conclusionsIn a population-based cohort of patients with Crohn's disease, the median cumulative length of total bowel resected was 64 cm during the follow-up period; the median rate of bowel loss due to resection was 4.2 cm annually.

Indexed as

AdolescentAdultAgedAged, 80 and overCohort StudiesCrohn DiseaseDigestive System Surgical ProceduresFemaleHumansMaleMiddle AgedMinnesotaRetrospective StudiesYoung AdultBowel DamageIBDOutcomeProgressionSurgery

Identifiers

PMID27155552
PMCPMC5028241
OpenAlexW2346148461

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.