ArticlePlant biotechnology journal2016
Identification and molecular characterization of the nicotianamine synthase gene family in bread wheat.
Article in Plant biotechnology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 73 citations in OpenAlex.
- Analysis of the TaNAS gene family in bread wheat identifies additional members and candidates for intragenic biofortification.Journal of experimental botany · 2026Article
- Genetic dissection of a key dynamic growth period QTL for source-sink-related traits and its breeding application potential in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- PGPR-induced regulation of Zn and Fe transporters in wheat (Triticum aestivum L.) uncovered through integrated genome-wide analysis and functional validation.BMC plant biology · 2026Article
- Identification of the Nicotianamine synthase (NAS) gene family in wheat (Triticum aestivum L.) and the role of its member TaNAS4-A in Zn and Fe transport.Functional & integrative genomics · 2025Article
- Transcriptomic and physiological analyses revealed nicotianamine enhances wheat tolerance to excess manganese.iScience · 2025Article
- Micronutrient Biofortification in Wheat: QTLs, Candidate Genes and Molecular Mechanism.International journal of molecular sciences · 2025Review
- Biofortification of Triticum species: a stepping stone to combat malnutrition.BMC plant biology · 2024Review
- Molecular characterization of stable QTL and putative candidate genes for grain zinc and iron concentrations in two related wheat populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
- Improving Zinc and Iron Biofortification in Wheat through Genomics Approaches.Molecular biology reports · 2022Review
- Exploring key developmental phases and phase-specific genes across the entirety of anther development in maize.Journal of integrative plant biology · 2022Article
- Combined morpho-physiological, ionomic and transcriptomic analyses reveal adaptive responses of allohexaploid wheat (Triticum aestivum L.) to iron deficiency.BMC plant biology · 2022Article
- Achieving nutritional security in India through iron and zinc biofortification in pearl millet (Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
- Genome-wide analysis of the NAAT, DMAS, TOM, and ENA gene families in maize suggests their roles in mediating iron homeostasis.BMC plant biology · 2022Article
- Strategies and Bottlenecks in Hexaploid Wheat to Mobilize Soil Iron to Grains.Frontiers in plant science · 2022Review
- Article
- Research and Progress on the Mechanism of Iron Transfer and Accumulation in Rice Grains.Plants (Basel, Switzerland) · 2021Review
- Molecular Responses to Cadmium Exposure in Two Contrasting Durum Wheat Genotypes.International journal of molecular sciences · 2021Article
- Functional mutants of Azospirillum brasilense elicit beneficial physiological and metabolic responses in Zea mays contributing to increased host iron assimilation.The ISME journal · 2021Article
- Annotation and Molecular Characterisation of theGenes · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotianamine (NA) is a non-protein amino acid involved in fundamental aspects of metal uptake, transport and homeostasis in all plants and constitutes the biosynthetic precursor of mugineic acid family phytosiderophores (MAs) in graminaceous plant species. Nicotianamine synthase (NAS) genes, which encode enzymes that synthesize NA from S-adenosyl-L-methionine (SAM), are differentially regulated by iron (Fe) status in most plant species and plant genomes have been found to contain anywhere from 1 to 9 NAS genes. This study describes the identification of 21 NAS genes in the hexaploid bread wheat (Triticum aestivum L.) genome and their phylogenetic classification into two distinct clades. The TaNAS genes are highly expressed during germination, seedling growth and reproductive development. Fourteen of the clade I NAS genes were up-regulated in root tissues under conditions of Fe deficiency. Protein sequence analyses revealed the presence of endocytosis motifs in all of the wheat NAS proteins as well as chloroplast, mitochondrial and secretory transit peptide signals in four proteins. These results greatly expand our knowledge of NAS gene families in graminaceous plant species as well as the genetics underlying Fe nutrition in bread wheat.
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