ArticleBiological psychology2016
Coordination of cortisol response to social evaluative threat with autonomic and inflammatory responses is moderated by stress appraisals and affect.
Article in Biological psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Coordination of inflammatory and adrenocortical stress response during pregnancy and variation by mental health.Brain, behavior, & immunity - health · 2025Article
- Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking.Psychoneuroendocrinology · 2025Article
- Salivary uric acid dynamics are associated with stress response hormones among African Americans in an urban sample.Psychoneuroendocrinology · 2024Article
- Interpersonal stress and proinflammatory activity in emerging adults with a history of suicide risk: A pilot study.Journal of mood and anxiety disorders · 2023Article
- Coordination of autonomic and endocrine stress responses to the Trier Social Stress Test in adolescence.Psychophysiology · 2022Article
- The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review.Medical journal of the Islamic Republic of Iran · 2022Review
- Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices.Psychoneuroendocrinology · 2021Review
- An experimental examination of worry and relaxation on cardiovascular, endocrine, and inflammatory processes.Psychoneuroendocrinology · 2020Article
- Reactivity of salivary uric acid in response to social evaluative stress in African Americans.Biological psychology · 2020Article
- Subjective social status and stress responsivity in late adolescence.Stress (Amsterdam, Netherlands) · 2020Article
- Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.Psychoneuroendocrinology · 2019Article
- Household fear of deportation in relation to chronic stressors and salivary proinflammatory cytokines in Mexican-origin families post-SB 1070.SSM - population health · 2018Article
- The cortisol:C-reactive protein ratio and negative affect reactivity in depressed adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- Biobehavioral Insights into Adaptive Behavior in Complex and Dynamic Operational Settings: Lessons learned from the Soldier Performance and Effective, Adaptable Response Task.Frontiers in medicine · 2017Article
- Concurrent and prospective associations between HPA axis activity and depression symptoms in newlywed women.Psychoneuroendocrinology · 2016Article
- Chronic occupational exposures can influence the rate of PTSD and depressive disorders in first responders and military personnel.Extreme physiology & medicine · 2016Article
- Associations between prenatal and postnatal substance exposure and salivary C-reactive protein in early childhood.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Recent approaches to stress regulation have emphasized coordination among multiple biological systems. This study builds on evidence that hypothalamic-pituitary-adrenal (HPA) axis activity should be considered in coordination with other stress-sensitive biological systems to characterize healthy responses. Healthy African-Americans (n=115) completed the Trier Social Stress Test, and biological responses were assessed through salivary cortisol, dehydroepiandrosterone-sulfate (DHEA-S), alpha amylase (sAA), and C-reactive protein (sCRP). Multilevel modeling demonstrated that cortisol responses typically aligned with changes in DHEA-S, sAA, and sCRP across the session. At the same time, the degree of cortisol coordination with sAA and sCRP varied by participants' subjective stress following the task; participants with higher secondary stress appraisals showed greater cortisol-sAA alignment, whereas those experiencing more negative affect showed greater cortisol-sCRP alignment. Results highlight the importance of a multisystem approach to stress and suggest that positive HPA axis coordination with the autonomic response, but not with the immune/inflammatory response, may be adaptive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.