ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic and Prognostic Potential of Tetranectin in Heart Failure and Cardiovascular Disease: A Systematic Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Unveiling the Mysteries of CLEC3B: Physiological Roles, Pathological Impacts, and Research Gaps.Cells · 2026Review
- Article
- Insight into the function of tetranectin in human diseases: A review and prospects for tetranectin-targeted disease treatment.Heliyon · 2024Review
- Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment.BMC cancer · 2021Article
- Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Dampening the Power of the Brain-When Aging Meets Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Article
- CLEC3B as a Potential Prognostic Biomarker in Hepatocellular Carcinoma.Frontiers in molecular biosciences · 2020Article
- CLEC3B protects H9c2 cardiomyocytes from apoptosis caused by hypoxia via the PI3K/Akt pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Whole-Exome Sequencing of an Exceptional Longevity Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- CLEC3B is downregulated and inhibits proliferation in clear cell renal cell carcinoma.Oncology reports · 2018Article
- C-type lectins in immunity and homeostasis.Nature reviews. Immunology · 2018Review
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life span is a complex trait regulated by multiple genetic and environmental factors; however, the genetic determinants of extreme longevity have been largely unknown. To identify the functional coding variants associated with extreme longevity, we performed an exome-wide association study (EWAS) on a Japanese population by using an Illumina HumanExome Beadchip and a focused replication study on a Chinese population. The EWAS on two independent Japanese cohorts consisting of 530 nonagenarians/centenarians demonstrated that the G allele of CLEC3B missense variant p.S106G was associated with extreme longevity at the exome-wide level of significance (p = 2.33×10-7, odds ratio [OR] = 1.50). The CLEC3B gene encodes tetranectin, a protein implicated in the mineralization process in osteogenesis as well as in the prognosis and metastasis of cancer. The replication study consisting of 448 Chinese nonagenarians/centenarians showed that the G allele of CLEC3B p.S106G was also associated with extreme longevity (p = .027, OR = 1.51), and the p value of this variant reached 1.87×10-8 in the meta-analysis of Japanese and Chinese populations. In conclusion, the present study identified the CLEC3B p.S106G as a novel longevity-associated variant, raising the novel hypothesis that tetranectin, encoded by CLEC3B, plays a role in human longevity and aging.
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