ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Aging, the Central Nervous System, and Mobility in Older Adults: Interventions.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- The association of a novel cognitive frailty index and physical functioning in older at-risk adults.Aging & mental health · 2020Trial
- Impact of Designated Recovery Rehabilitation Institutions on the Readmission Rate of Older Adults.Journal of clinical medicine · 2026Article
- The Link Between Physical Fitness and Cognitive Function in Vulnerable Low-Income Older Adults from Amazonas, Brazil.Healthcare (Basel, Switzerland) · 2026Article
- Physical disability and risk of incident hypertension: a prospective cohort analysis.Journal of human hypertension · 2025Article
- Sex Differences in the Association Between Physical Functioning and Cognition in Two Central European Populations.European journal of neurology · 2025Article
- Predictors of walking ability at discharge post proximal femoral fracture in an acute care hospital.Journal of physical therapy science · 2025Article
- Protocol for a home-based self-delivered prehabilitation intervention to proactively reduce fall risk in older adults: a pilot randomized controlled trial of transcranial direct current stimulation and motor imagery.Pilot and feasibility studies · 2024Article
- Article
- Discriminative Mobility Characteristics between Neurotypical Young, Middle-Aged, and Older Adults Using Wireless Inertial Sensors.Sensors (Basel, Switzerland) · 2021Article
- Peripheral Nerve Impairment in a Mouse Model of Alzheimer's Disease.Brain sciences · 2021Article
- Is impaired dopaminergic function associated with mobility capacity in older adults?GeroScience · 2021Article
- Cardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats.Frontiers in aging neuroscience · 2021Article
- Mobility in Older Community-Dwelling Persons: A Narrative Review.Frontiers in physiology · 2020Review
- Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors.NeuroImage. Clinical · 2020Article
- A Narrative Review of Handgrip Strength and Cognitive Functioning: Bringing a New Characteristic to Muscle Memory.Journal of Alzheimer's disease : JAD · 2020Review
- Association Between Physical Performance and Cognitive Function in Older Adults Across Multiple Studies: A Pooled Analysis Study.Innovation in aging · 2020Article
- Using Dual-Site Transcranial Magnetic Stimulation to Probe Connectivity between the Dorsolateral Prefrontal Cortex and Ipsilateral Primary Motor Cortex in Humans.Brain sciences · 2019Article
- Acute Effects of Whole-Body Vibration on the Postural Organization of Gait Initiation in Young Adults and Elderly: A Randomized Sham Intervention Study.Frontiers in neurology · 2019Article
- The Aging Brain & the Dorsal Basal Ganglia: Implications for Age-Related Limitations of Mobility.Advances in geriatric medicine and research · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundResearch suggests that the central nervous system (CNS) and mobility are closely linked. CNS-mediated mobility impairment may represent a potentially new and prevalent syndrome within the older adult populations. Interventions targeting this group may have the potential to improve mobility and cognition and prevent disability.
methodsIn 2012, the Gerontological Society of America (GSA) and the National Institute on Aging (NIA) sponsored a 3-year conference workshop series, "Aging, the CNS, and Mobility." The goal of this third and final conference was to (i) report on the state of the science of interventions targeting CNS-mediated mobility impairment among community-dwelling older adults and (ii) partnering with the NIA, explore the future of research and intervention design focused on a potentially novel aging syndrome.
resultsEvidence was presented in five main intervention areas: (i) pharmacology and diet; (ii) exercise; (iii) electrical stimulation; (iv) sensory stimulation/deprivation; and (v) a combined category of multimodal interventions. Workshop participants identified important gaps in knowledge and key recommendations for future interventions related to recruitment and sample selection, intervention design, and methods to measure effectiveness.
conclusionsIn order to develop effective preventive interventions for this prevalent syndrome, multidisciplinary teams are essential particularly because of the complex nature of the syndrome. Additionally, integrating innovative methods into the design of interventions may help researchers better measure complex mechanisms, and finally, the value of understanding the link between the CNS and mobility should be conveyed to researchers across disciplines in order to incorporate cognitive and mobility measurements into study protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.