Evidence map›Paper›PMID 27154859›Full record

ReviewPhysical medicine and rehabilitation clinics of North America2016

Potential Long-Term Consequences of Concussive and Subconcussive Injury.

Bertrand R Huber, Michael L Alosco, Thor D Stein, Ann C McKee

Abstract readReview
In one paragraph

Review in Physical medicine and rehabilitation clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bertrand R HuberVA Boston HealthCare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Department of Neurology, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA.
Michael L AloscoChronic Traumatic Encephalopathy Program, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA.
Thor D SteinVA Boston HealthCare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA; Department of Pathology, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA; Bedford Veterans Affairs Medical Center, 200 Springs Road, Building 18, Room 118, Bedford, MA 01730, USA.
Ann C McKeeVA Boston HealthCare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Department of Neurology, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA; Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA; Department of Pathology, Boston University School of Medicine, 72 East Concord Street, B-7800, Boston, MA 02118, USA. Electronic address: amckee@bu.edu.

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo ImagingU01NS086659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2014 to 2017
$6.1M
Alzheimer's disease translational research trainingT32AG036697 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 2011 to 2015
$1.1M
Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic EncephalopathyF32NS096803 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALOSCO, MICHAEL · 2016 to 2017
$118k
Tau Biomarkers following Blast mTBI in OEF/OIF VeteransI01RX000991 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MCKEE, ANN C. · 2015 to 2018
–
Intramural VA VA999999NIA NIH HHS P30 AG013846NIA NIH HHS T32 AG036697NINDS NIH HHS F32 NS096803NINDS NIH HHS U01 NS086659RRD VA I01 RX000991
6 · The paper itself

Abstract

Repeated concussive and subconcussive trauma is associated with the later development of chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with clinical symptoms in multiple domains and a unique pattern of pathologic changes. CTE has been linked to boxing and American football; CTE has also been identified in soccer, ice hockey, baseball, rugby, and military service. To date, most large studies of CTE have come from enriched cohorts associated with brain bank donations for traumatic brain injury, although several recent studies re-examining neurodegenerative disease brain banks suggest that CTE is more common than is currently appreciated.

Indexed as

BrainBrain ConcussionBrain InjuriesBrain Injuries, TraumaticBrain Injury, ChronicChronic Traumatic EncephalopathyHumansChronic traumatic encephalopathyConcussionNeuropathologySubconcussionTauTraumaTraumatic brain injury

Identifiers

PMID27154859
PMCPMC4866819

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.