ArticleThe Journal of general virology2016
Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus.
Article in The Journal of general virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.
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Who cites it
134 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- Virus Metagenomics in Farm Animals: A Systematic Review.Viruses · 2020Pooled it
- Nasal shedding of bovine coronavirus during commingling is associated with reduced average daily gain and lung lesions in weaned seropositive calves.Journal of dairy science · 2026Article
- The calf holobiont under challenge: longitudinal microbiota-pathogen dynamics and respiratory health.Veterinary research · 2026Article
- Occurrence of respiratory and enteric bacteria and viruses in calves in Iceland.Acta veterinaria Scandinavica · 2026Article
- Comparison of short nasal swab and deep nasopharyngeal swab sampling methods to describe BRD-associated viruses and bacteria detected using a metagenomics approach optimized for virus recovery in fall-placed beef calves shortly after feedlot arrival.Veterinary and animal science · 2026Article
- Molecular Characterisation, Isolation, and Antibody Response to Influenza D Virus in Naturally Infected Cattle.Viruses · 2026Article
- A serological survey of influenza D virus infection in cattle in Hokkaido, Japan.The Journal of veterinary medical science · 2026Article
- Development of an influenza D virus with an eight- or nine-segment genome.Scientific reports · 2026Article
- Diagnostic sensitivity and specificity of metagenomic sequencing and qPCR for detection of viruses associated with bovine respiratory disease estimated using Bayesian latent class models.Frontiers in veterinary science · 2026Article
- Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms.Transboundary and emerging diseases · 2026Article
- Next-generation detection in bovine respiratory and enteric diseases: metagenomic and amplicon sequencing insights into microbial diversity.Frontiers in veterinary science · 2026Review
- Diagnostic Methods for Bovine Coronavirus: A Review of Recent Advancements and Challenges.Viruses · 2025Review
- A Comprehensive Review: Molecular Diagnostics and Multi-Omics Approaches to Understanding Bovine Respiratory Disease.Veterinary sciences · 2025Review
- Pathological and molecular findings associated with BRSV in cattle and buffaloes with pulmonary disease.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Seroprevalence of influenza C and D virus infections among cattle in Japan.Veterinary and animal science · 2025Article
- Development of a Conventional Reverse Transcription-PCR System for Broad Detection of Bovine Rhinitis A Virus.Veterinary medicine and science · 2025Article
- A Comprehensive Review: Bovine Respiratory Disease, Current Insights into Epidemiology, Diagnostic Challenges, and Vaccination.Veterinary sciences · 2025Review
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- Genomic Characterization of Two Bovine Enterovirus Strains Isolated from Newly Transported Cattle.Veterinary sciences · 2025Article
- Genome sequence of a Tetraparvovirus ungulate 1 strain from a cow in Tennessee, USA.Microbiology resource announcements · 2025Article
74 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bovine respiratory disease (BRD) is the most costly disease affecting the cattle industry. The pathogenesis of BRD is complex and includes contributions from microbial pathogens as well as host, environmental and animal management factors. In this study, we utilized viral metagenomic sequencing to explore the virome of nasal swab samples obtained from feedlot cattle with acute BRD and asymptomatic pen-mates at six and four feedlots in Mexico and the USA, respectively, in April-October 2015. Twenty-one viruses were detected, with bovine rhinitis A (52.7 %) and B (23.7 %) virus, and bovine coronavirus (24.7 %) being the most commonly identified. The emerging influenza D virus (IDV) tended to be significantly associated (P=0.134; odds ratio=2.94) with disease, whereas viruses commonly associated with BRD such as bovine viral diarrhea virus, bovine herpesvirus 1, bovine respiratory syncytial virus and bovine parainfluenza 3 virus were detected less frequently. The detection of IDV was further confirmed using a real-time PCR assay. Nasal swabs from symptomatic animals had significantly more IDV RNA than those collected from healthy animals (P=0.04). In addition to known viruses, new genotypes of bovine rhinitis B virus and enterovirus E were identified and a newly proposed species of bocaparvovirus, Ungulate bocaparvovirus 6, was characterized. Ungulate tetraparvovirus 1 was also detected for the first time in North America to our knowledge. These results illustrate the complexity of the virome associated with BRD and highlight the need for further research into the contribution of other viruses to BRD pathogenesis.
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