ArticleBMC pharmacology & toxicology2016
Temporal trends in the utilization of vasopressors in intensive care units: an epidemiologic study.
Article in BMC pharmacology & toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis.Critical care (London, England) · 2025Pooled it
- Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis.Acta anaesthesiologica Scandinavica · 2019Pooled it
- Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial.Intensive care medicine · 2020Trial
- Midodrine as adjunctive support for treatment of refractory hypotension in the intensive care unit: a multicenter, randomized, placebo controlled trial (the MIDAS trial).BMC anesthesiology · 2017Trial
- Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026.Intensive care medicine · 2026Article
- Strategies for discontinuing vasopressin and norepinephrine during the recovery phase of shock: a single-center retrospective study.Journal of intensive care · 2025Article
- Real-time prediction of intensive care unit patient acuity and therapy requirements using state-space modelling.Nature communications · 2025Article
- Oral blood pressure augmenting agents for intravenous vasopressor weaning.World journal of clinical cases · 2024Review
- Pulmonary Embolism in Critically Ill Patients-Prevention, Diagnosis, and Management.Diagnostics (Basel, Switzerland) · 2024Review
- APRICOT-Mamba: Acuity Prediction in Intensive Care Unit (ICU): Development and Validation of a Stability, Transitions, and Life-Sustaining Therapies Prediction Model.Research square · 2024Article
- Identifying inpatient hospitalizations with continuous electroencephalogram monitoring from administrative data.BMC health services research · 2023Article
- Oral Midodrine as an Adjunct in Rapid Weaning of Intravenous Vasopressor Support in Spinal Cord Injury.Asian journal of neurosurgery · 2023Article
- An improved prognostic model for predicting the mortality of critically ill patients: a retrospective cohort study.Scientific reports · 2022Article
- Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis.BMJ open · 2022Article
- Association of Sequential Organ Failure Assessment (SOFA) components with mortality.Acta anaesthesiologica Scandinavica · 2022Article
- Article
- Timing of vasoactive agents and corticosteroid initiation in septic shock.Annals of intensive care · 2022Review
- The order of vasopressor discontinuation and incidence of hypotension: a retrospective cohort analysis.Scientific reports · 2021Article
- Characteristics and outcomes of patients admitted to adult intensive care units in Hong Kong: a population retrospective cohort study from 2008 to 2018.Journal of intensive care · 2021Article
- Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure.Intensive care medicine experimental · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe choice of vasopressor use in the intensive care unit (ICU) depends primarily on provider preference. This study aims to describe the rate of vasopressor utilization and the trends of each vasoactive agent usage in the ICU over the span of 7 years in a tertiary referral center.
methodsAll adult ICU admissions, including medical, cardiac, and surgical ICUs from January 1st, 2007 through December 31st, 2013 were included in this study. Vasopressor use was defined as the continuous intravenous administration of epinephrine, norepinephrine, phenylephrine, dopamine, or vasopressin within a given ICU day. The vasopressor utilization index (VUI) was defined as the proportion of ICU days on each vasoactive agent divided by the total ICU days with vasopressor usage.
resultsDuring the study period, 72,005 ICU admissions and 272,271 ICU days were screened. Vasopressors were used in 19,575 ICU admissions (27 %) and 59,811 ICU days (22 %). Vasopressin was used in 24,496 (41 %), epinephrine in 23,229 (39 %), norepinephrine in 20,648 (34 %), dopamine in 9449 (16 %), and phenylephrine in 7508 (13 %) ICU days. The VUInorepinephrine increased from 0.24 in 2007 to 0.46 in 2013 and VUIphenylephrine decreased from 0.20 in 2007 to 0.08 in 2013 (p < 0.001 both). For epinephrine, dopamine, and vasopressin VUI did not change over the course of study.
conclusionVasopressors were used in about one fourth of ICU admissions and about one-fifth of ICU days. Although vasopressin is the most commonly used vasopressor, the use of norepinephrine found to have an increasing trajectory.
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