ArticleCirculation. Heart failure2016
Relationship Between Anticoagulation Intensity and Thrombotic or Bleeding Outcomes Among Outpatients With Continuous-Flow Left Ventricular Assist Devices.
Article in Circulation. Heart failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 100 citations in OpenAlex.
- Trial
- CT-based cannula position predicts neurological risk in patients with HeartMate 3 LVAD.JHLT open · 2026Article
- Advances in Mechanical Circulatory Support (MCS): Literature Review.Biomedicines · 2025Review
- The association between liver function tests abnormalities and type 2 diabetes mellitus patients in Saudi Arabia: a cross-sectional study.Frontiers in clinical diabetes and healthcare · 2025Article
- Anesthetic management for non-cardiac surgery in patients with left ventricular assist devices.Korean journal of anesthesiology · 2024Review
- Antithrombotic therapy for durable left ventricular assist devices - current strategies and future directions.Indian journal of thoracic and cardiovascular surgery · 2022Review
- Left ventricular assist device-related infections and the risk of cerebrovascular accidents: a EUROMACS study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
- Different risks of hemorrhage in patients with elevated international normalized ratio from chronic liver disease versus warfarin therapy, a population-based retrospective cohort study.Journal of thrombosis and haemostasis : JTH · 2022Article
- Pump thrombosis and dynamic outflow graft compression: complications in left ventricular assist device therapy.ESC heart failure · 2021Article
- Psychosocial Risk and Its Association With Outcomes in Continuous-Flow Left Ventricular Assist Device Patients.Circulation. Heart failure · 2020Article
- Outcomes following left ventricular assist device exchange.Journal of cardiac surgery · 2020Article
- Clinical Approach to Manage Gastrointestinal Bleeding with a Left Ventricular Assist Device (LVAD).Cureus · 2019Review
- Hemostatic complications associated with ventricular assist devices.Research and practice in thrombosis and haemostasis · 2019Review
- Device-induced platelet dysfunction in mechanically assisted circulation increases the risks of thrombosis and bleeding.Artificial organs · 2019Article
- Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019Article
- Optimal haemodynamics during left ventricular assist device support are associated with reduced haemocompatibility-related adverse events.European journal of heart failure · 2019Article
- Stroke Incidence and Impact of Continuous-Flow Left Ventricular Assist Devices on Cerebrovascular Physiology.Stroke · 2019Article
- Impact of body mass index on adverse events after implantation of left ventricular assist devices: An IMACS registry analysis.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- Cerebrovascular Events After Continuous-Flow Left Ventricular Assist Devices.Neurocritical care · 2018Article
- Identification of Novel Hemostatic Biomarkers of Adverse Clinical Events in Patients Implanted With a Continuous-Flow Left Ventricular Assist Device.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe evaluated thrombotic and bleeding outcomes in patients with continuous-flow left ventricular assist devices (CF-LVADs), stratified by anticoagulation intensity. Previous studies of outpatients with CF-LVADs have suggested that target international normalized ratio (INR) values <2.5 (range, 2-3) may be used. However, recent studies reported an increase in pump thrombosis among CF-LVADs, especially within the first 6 months of implant. METHODS AND
resultsWe retrospectively reviewed 249 outpatients at our center who received a CF-LVAD between January 2005 and August 2013. Using Poisson models, we analyzed their 10 927 INRs to determine INR-specific rates of thrombotic (ischemic stroke and suspected pump thrombosis) and hemorrhagic (gastrointestinal bleeding and hemorrhagic stroke) events occurring outside of the hospital. In multivariate analyses, we adjusted for age, sex, atrial fibrillation, coronary disease, and LVAD type as time-dependent Cox proportional hazard models. During a mean follow-up of 17.6±13.6 months, thrombotic events occurred in 46 outpatients. The highest event rate (0.40 thrombotic events per patient-year) was in the INR range of <1.5, but INR values of 1.5 to 1.99 also had high rates (0.16 thrombotic events per patient-year). INR was inversely associated with thrombotic events (hazard ratio, 0.40; 95% confidence interval, 0.22-0.72; P=0.002). The optimal INR based on weighted mortality of thrombotic and bleeding events was 2.6.
conclusionsINR is inversely related to thrombotic events occurring outside of the hospital among patients supported with CF-LVADs. INR values <2.0 increase the rate of thrombotic events occurring outside of the hospital among patients supported with CF-LVADs.
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