ArticleEMBO reports2016
TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe.
Article in EMBO reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 80 citations in OpenAlex.
- A TERRA-NONO axis drives fibroblast reprogramming in cancer.Science advances · 2026Article
- Molecular and functional characterization of telomeric repeat-containing RNAs in Chinese hamster ovary cells.Nucleic acids research · 2026Article
- Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026Review
- TERRA and the alternative lengthening of telomeres: a dangerous affair.FEBS letters · 2025Review
- TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends.Science advances · 2024Article
- Telomeres as hotspots for innate immunity and inflammation.DNA repair · 2024Review
- Telomeric repeat-containing RNA is dysregulated in acute myeloid leukemia.Blood advances · 2023Article
- TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.Nucleic acids research · 2023Article
- TERRA and Telomere Maintenance in the YeastGenes · 2023Review
- Review
- TERRA beyond cancer: the biology of telomeric repeat-containing RNAs in somatic and germ cells.Frontiers in aging · 2023Review
- Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts inRNA biology · 2023Article
- To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks.Cells · 2022Review
- In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2.International journal of molecular sciences · 2022Article
- NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length.Biochemistry and biophysics reports · 2022Article
- Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials.PLoS genetics · 2022Article
- TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer.Frontiers in oncology · 2022Review
- The makings of TERRA R-loops at chromosome ends.Cell cycle (Georgetown, Tex.) · 2021Review
- TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells.Nature communications · 2021Article
- TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain.Nucleic acids research · 2021Article
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8 authors at 2 institutions in 2 countries.
Funding
Abstract
Telomerase-mediated telomere elongation provides cell populations with the ability to proliferate indefinitely. Telomerase is capable of recognizing and extending the shortest telomeres in cells; nevertheless, how this mechanism is executed remains unclear. Here, we show that, in the fission yeast Schizosaccharomyces pombe, shortened telomeres are highly transcribed into the evolutionarily conserved long noncoding RNA TERRA A fraction of TERRA produced upon telomere shortening is polyadenylated and largely devoid of telomeric repeats, and furthermore, telomerase physically interacts with this polyadenylated TERRA in vivo We also show that experimentally enhanced transcription of a manipulated telomere promotes its association with telomerase and concomitant elongation. Our data represent the first direct evidence that TERRA stimulates telomerase recruitment and activity at chromosome ends in an organism with human-like telomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.