Evidence map›Paper›PMID 27154393›Full record

ArticleVaccine2016

Hendra virus and Nipah virus animal vaccines.

Christopher C Broder, Dawn L Weir, Peter A Reid

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. One health (Amsterdam, Netherlands) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Nipah virus: pathogenesis, genome, diagnosis, and treatment.Applied microbiology and biotechnology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. AnFrontiers in chemical biology · 2024
    Article
  13. Review
  14. Recombinant Cedar Virus: A Henipavirus Reverse Genetics Platform.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  15. Article
  16. Recombinant Soluble Henipavirus Glycoprotein Preparation.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  17. In Vitro Antiviral Screening for Henipaviruses at BSL4.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. Article
  19. Article
  20. Henipaviruses-A constant threat to livestock and humans.PLoS neglected tropical diseases · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christopher C BroderDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, 20814, United States. Electronic address: christopher.broder@usuhs.edu.
Dawn L WeirNavy Environmental and Preventive Medicine Unit Six, Joint Base Pearl Harbor Hickam, HI, 96860, United States.
Peter A ReidEquine Veterinary Surgeon, Brisbane, Queensland, 4034, Australia.
Joint Typhoon Warning Center · USUniformed Services University of the Health Sciences · US

Funding

Nipah & Hendra Virus Nonhuman Primate Model & Therapeutics DevelopmentU01AI082121 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GEISBERT, THOMAS WILLIAM · 2009 to 2013
$5.9M
Vaccines and Therapeutics for Nipah and Hendra virusU01AI077995 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BRODER, CHRISTOPHER C · 2008 to 2012
$5.5M
Nipah Virus and Hendra Virus Entry and Virion AssemblyR01AI054715 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BRODER, CHRISTOPHER C · 2006 to 2016
$3.1M
NIAID NIH HHS R01 AI054715NIAID NIH HHS U01 AI077995NIAID NIH HHS U01 AI082121
6 · The paper itself

Abstract

Hendra virus (HeV) and Nipah virus (NiV) are zoonotic viruses that emerged in the mid to late 1990s causing disease outbreaks in livestock and people. HeV appeared in Queensland, Australia in 1994 causing a severe respiratory disease in horses along with a human case fatality. NiV emerged a few years later in Malaysia and Singapore in 1998-1999 causing a large outbreak of encephalitis with high mortality in people and also respiratory disease in pigs which served as amplifying hosts. The key pathological elements of HeV and NiV infection in several species of mammals, and also in people, are a severe systemic and often fatal neurologic and/or respiratory disease. In people, both HeV and NiV are also capable of causing relapsed encephalitis following recovery from an acute infection. The known reservoir hosts of HeV and NiV are several species of pteropid fruit bats. Spillovers of HeV into horses continue to occur in Australia and NiV has caused outbreaks in people in Bangladesh and India nearly annually since 2001, making HeV and NiV important transboundary biological threats. NiV in particular possesses several features that underscore its potential as a pandemic threat, including its ability to infect humans directly from natural reservoirs or indirectly from other susceptible animals, along with a capacity of limited human-to-human transmission. Several HeV and NiV animal challenge models have been developed which have facilitated an understanding of pathogenesis and allowed for the successful development of both active and passive immunization countermeasures.

Indexed as

Hendra VirusNipah VirusAnimalsChiropteraHenipavirus InfectionsHorsesHumansImmunization, PassiveSwineVaccinationViral VaccinesZoonosesViral VaccinesAnimal modelsAntiviralHendraHenipavirusMonoclonal antibodyNipahParamyxovirusPathogenesisVaccine

Identifiers

PMID27154393
PMCPMC4933500
OpenAlexW2345925747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.