ReviewDrugs2016
Ongoing Pharmacological Management of Chronic Pain in Pregnancy.
Review in Drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Prescription use of acetaminophen among pregnant women in Denmark from 2000 to 2023: A drug utilization study.British journal of clinical pharmacology · 2026Article
- Neonatal abstinence syndrome hospitalizations in Canada: a descriptive study.Canadian journal of public health = Revue canadienne de sante publique · 2023Article
- Medication use during pregnancy among women with congenital physical disabilities.Birth defects research · 2022Article
- Paracetamol use during pregnancy - a call for precautionary action.Nature reviews. Endocrinology · 2021Review
- Early exposure of pregnant women to non-steroidal anti-inflammatory drugs delivered outside hospitals and preterm birth risk: nationwide cohort study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Use and Intentional Avoidance of Prescribed Medications in Pregnancy: A Cross-Sectional, Web-Based Study among 926 Women in Italy.International journal of environmental research and public health · 2020Article
- Rheumatologic Medication Use During Pregnancy.Obstetrics and gynecology · 2020Review
- Medication Use among Pregnant Women from the 2015 Pelotas (Brazil) Birth Cohort Study.International journal of environmental research and public health · 2020Article
- Detection of opioids in umbilical cord lysates: an antibody-based rapid screening approach.Toxicology mechanisms and methods · 2019Article
- Substance use in pregnancy: The medical challenge.Obstetric medicine · 2018Review
- Drug use in pregnant women-a pilot study of the coherence between reported use of drugs and presence of drugs in plasma.European journal of clinical pharmacology · 2018Article
- Medical abortions among university students in Ghana: implications for reproductive health education and management.International journal of women's health · 2018Article
- Pain and Depression Symptoms During the Third Trimester of Pregnancy.MCN. The American journal of maternal child nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The article discusses possible effects of the use of analgesics during pregnancy. It summarizes the pertinent literature and reports some previously unpublished data from the Swedish Medical Birth Register. Most likely the use of analgesics does not cause spontaneous abortion. Only small malformation risk increases are seen after the use of opioids and perhaps non-steroid anti-inflammatory drug (NSAID) use. If possible, the latter should be avoided during the first trimester. If exposure has occurred there is no reason to consider an interruption of the pregnancy. Continued use of analgesics may increase the risk of preeclampsia and of preterm birth, especially valid for opioids. Use of acetylsalicylic acid (ASA) in late pregnancy should be avoided because of the risk of bleeding and (valid also for NSAIDs) premature closure of the ductus arteriosus. A small risk for neonatal abstinence syndrome may exist after the use of opioids for chronic pain, notably during the third trimester and long-lasting effects on child development can possibly occur. For a woman with chronic pain, adequate use of pain killers during pregnancy is needed. It is prudent to avoid ASA and NSAIDs towards the end of the pregnancy, while acetaminophen is an acceptable option all through pregnancy. If continued use of opioids is necessary, the associated risks are low. Triptans can be used for migraine during pregnancy. If possible sumatriptan is preferable to other triptans as data for the latter are largely lacking. Ergots are preferably avoided as not enough data are available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.