Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD.

Sandra Almeida, Fen-Biao Gao

Abstract readComment

In one paragraph

Article in The EMBO journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Amyotrophic Lateral Sclerosis: Focus on Cytoplasmic Trafficking and Proteostasis.Molecular neurobiology · 2025
Review
How villains are made: The translation of dipeptide repeat proteins in C9ORF72-ALS/FTD.Gene · 2023
Review
C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice.Frontiers in cellular neuroscience · 2023
Article
Autophagy in health and disease: From molecular mechanisms to therapeutic target.MedComm · 2022
Review
Autophagy and ALS: mechanistic insights and therapeutic implications.Autophagy · 2022
Review
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.Neuron · 2021
Article
Molecular Genetics of Frontotemporal Dementia Elucidated byInternational journal of molecular sciences · 2018
Review
Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.The EMBO journal · 2017
Review

4 · The record

Corrections and comments

Comment on
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.2016

5 · Who and what money

Authors and funding

2 authors.

Sandra AlmeidaDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

Fen-Biao GaoDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

Funding

Investigating Common Molecular Pathogenic Pathways in Frontotemporal Dementia Patients iPSC-Derived NeuronsR01NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2008 to 2026

$4.5M

Frontotemporal Dementia Induced Pluripotent Stem Cell ConsortiumR01NS079725 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI GAO, FEN-BIAO, HUANG, YADONG · 2013 to 2016

$3.1M

NINDS NIH HHS R01 NS057553NINDS NIH HHS R01 NS079725

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisAutophagyFrontotemporal DementiaHumansProteinsProteins

Identifiers

PMID27154207

DOI10.15252/embj.201694578

PMCPMC4910530

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.