ArticlePsychoneuroendocrinology2016
Corticotropin releasing factor type-1 receptor antagonism in the dorsolateral bed nucleus of the stria terminalis disrupts contextually conditioned fear, but not unconditioned fear to a predator odor.
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- BNST CRF receptor type 1 modulates mechanical hypersensitivity induced by adolescent alcohol exposure in adult female mice.Psychopharmacology · 2024Article
- Article
- Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas.Journal of neuroinflammation · 2022Article
- Corticotropin releasing factor (CRF) systems: Promoting cocaine pursuit without distress via incentive motivation.PloS one · 2022Article
- Hyperexcitability: From Normal Fear to Pathological Anxiety and Trauma.Frontiers in systems neuroscience · 2022Review
- Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment.Scientific reports · 2019Article
- Defining circuit-specific roles for G protein-coupled receptors in aversive learning.Current opinion in behavioral sciences · 2019Article
- Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies-potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST).Cell and tissue research · 2019Review
- Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear.Molecular psychiatry · 2018Article
- Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System.Neural plasticity · 2018Review
- Pharmacological Manipulation of DNA Methylation in Adult Female Rats Normalizes Behavioral Consequences of Early-Life Maltreatment.Frontiers in behavioral neuroscience · 2018Article
- Conservatism and the neural circuitry of threat: economic conservatism predicts greater amygdala-BNST connectivity during periods of threat vs safety.Social cognitive and affective neuroscience · 2018Article
- Role of the bed nucleus of the stria terminalis in aversive learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
The bed nucleus of the stria terminalis (BNST) plays a critical role in fear and anxiety. The BNST is important for contextual fear learning, but the mechanisms regulating this function remain unclear. One candidate mechanism is corticotropin-releasing-factor (CRF) acting at CRF type 1 receptors (CRFr1s). Yet, there has been little progress in elucidating if CRFr1s in the BNST are involved in different types of fear (conditioned and/or unconditioned). Therefore, the present study investigated the effect of antalarmin, a potent CRFr1 receptor antagonist, injected intracerebroventricularly (ICV) and into the dorsolateral BNST (LBNST) during single trial contextual fear conditioning or exposure to the predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT). Neither ICV nor LBNST antalarmin disrupted unconditioned freezing to TMT. In contrast, ICV and LBNST antalarmin disrupted the retention of contextual fear when tested 24h later. Neither ICV nor LBNST antalarmin affected baseline or post-shock freezing-indicating antalarmin does not interfere with the early phases of contextual fear acquisition. Antalarmin did not (1) permanently affect the ability to learn and express contextual fear, (2) change responsivity to footshocks, or (3) affect the ability to freeze. Our findings highlight an important role for CRFr1s within the LBNST during contextually conditioned fear, but not unconditioned predator odor fear.
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