ArticleEnvironmental health perspectives2016
Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Pooled it
- Pesticide exposure and child growth in low- and middle-income countries: A systematic review.Environmental research · 2022Pooled it
- Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models.International journal of environmental research and public health · 2021Pooled it
- Cohort profile: Sheyang Mini Birth Cohort Study (SMBCS).BMJ open · 2026Article
- Prenatal Exposure to Organochlorine Compounds and Other Pesticides: A Systematic Review of Neonatal Health Outcomes.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Unraveling genetic risk contributions to nonverbal status in autism spectrum disorder probands.Behavioral and brain functions : BBF · 2025Article
- A birth cohort observational study to assess the association of prenatal biomarkers of organophosphates with visual attention, recognition memory and information processing among Thai infants.Environmental research · 2025Observational
- Can behavioural nudges promote reduced-salt dish orders on meal delivery apps?Public health · 2025Article
- Analysis of Chlorpyrifos Pesticide Residue in Locally Grown Cauliflower, Cabbage, and Eggplant Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique: A Bangladesh Perspective.Foods (Basel, Switzerland) · 2024Article
- Pesticide exposure, birth size, and gestational age in the ISA birth cohort, Costa Rica.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Genetic analysis of a pedigree with MECP2 duplication syndrome in China.BMC medical genomics · 2024Article
- Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications.Frontiers in public health · 2024Review
- Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study.Environmental health perspectives · 2023Article
- Autistic clinical profiles, age at first concern, and diagnosis among children with autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Clinical and genetic characteristics of 36 children with Joubert syndrome.Frontiers in pediatrics · 2023Article
- Prenatal organophosphorus pesticide exposure and executive function in preschool-aged children in the Norwegian Mother, Father and Child Cohort Study (MoBa).Environmental research · 2022Article
- Atypical deletion of Williams-Beuren syndrome reveals the mechanism of neurodevelopmental disorders.BMC medical genomics · 2022Article
- Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children.Frontiers in molecular neuroscience · 2022Article
- Effect of Flutriafol Exposure on Residue Characteristics in Pig Muscle and Fat Tissue.Food science of animal resources · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrenatal exposure to organophosphorous (OP) pesticides has been found to be associated with adverse effects on child neurodevelopment, but evidence on potential effects induced by both prenatal and postnatal OP exposure in infants is limited.
objectivesOur aim was to investigate the associations of both prenatal and postnatal OP exposure with birth outcomes and infant neurodevelopment.
methodsExposure to OP in 310 mother-infant pairs was assessed by measuring dimethylphosphate (DM), diethylphosphate (DE), and total dialkylphosphate (DAP) metabolites in urines from pregnant women and their children at 2 years of age. The Gesell Developmental Schedules was administered to examine neurodevelopment of 2-year-old children.
resultsBased on the Gesell Developmental Schedules, the proportions of children with developmental delays were < 6%. Adverse associations between head circumference at birth and prenatal OP exposure were demonstrated. Both prenatal and postnatal OP exposure was significantly associated with increased risk of being developmentally delayed. Specifically, odds ratio (OR) value for prenatal DEs was 9.75 (95% CI: 1.28, 73.98, p = 0.028) in the adaptive area, whereas in the social area, OR values for postnatal DEs and DAPs were 9.56 (95% CI: 1.59, 57.57, p = 0.014) and 12.00 (95% CI: 1.23, 117.37, p = 0.033), respectively. Adverse associations were observed only in boys, not in girls.
conclusionsBoth prenatal and postnatal OP exposure may adversely affect the neurodevelopment of infants living in the agricultural area. The present study adds to the accumulating evidence on associations of prenatal and postnatal OP exposure with infant neurodevelopment. CITATION: Liu P, Wu C, Chang X, Qi X, Zheng M, Zhou Z. 2016. Adverse associations of both prenatal and postnatal exposure to organophosphorous pesticides with infant neurodevelopment in an agricultural area of Jiangsu Province, China. Environ Health Perspect 124:1637-1643; http://dx.doi.org/10.1289/EHP196.
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Registered trials
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