ArticlePLoS genetics2016
Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of Nematodes.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?Ecology and evolution · 2025Review
- Review
- Counter-attack of biocontrol agents: Environmentally benign Approaches against Root-knot nematodes (Heliyon · 2023Review
- The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.EMBO reports · 2023Article
- Nematophagous Fungi: A Review of Their Phosphorus Solubilization Potential.Microorganisms · 2023Review
- C. elegans: out on an evolutionary limb.Immunogenetics · 2022Review
- Root-knot nematodes (Meloidogyne spp.) a threat to agriculture in Mexico: biology, current control strategies, and perspectives.World journal of microbiology & biotechnology · 2022Review
- Comparative Genomics of ThreeFrontiers in microbiology · 2022Article
- Pathogenicity and Metabolites of Endoparasitic Nematophagous FungusMicroorganisms · 2021Article
- Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.PLoS genetics · 2021Article
- Ubiquitin-related processes and innate immunity in C. elegans.Cellular and molecular life sciences : CMLS · 2021Review
- Putative LysM Effectors Contribute to Fungal Lifestyle.International journal of molecular sciences · 2021Article
- Innate immunity in C. elegans.Current topics in developmental biology · 2021Review
- Increased Pathogenicity of the Nematophagous FungusFrontiers in fungal biology · 2021Article
- Fungi-Nematode Interactions: Diversity, Ecology, and Biocontrol Prospects in Agriculture.Journal of fungi (Basel, Switzerland) · 2020Review
- Long-read only assembly of Drechmeria coniospora genomes reveals widespread chromosome plasticity and illustrates the limitations of current nanopore methods.GigaScience · 2020Article
- Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans.PLoS genetics · 2019Article
- Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans.Virulence · 2018Article
- Evolutionary plasticity in the innate immune function of Akirin.PLoS genetics · 2018Article
- Genome and secretome analysis of Pochonia chlamydosporia provide new insight into egg-parasitic mechanisms.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drechmeria coniospora is an obligate fungal pathogen that infects nematodes via the adhesion of specialized spores to the host cuticle. D. coniospora is frequently found associated with Caenorhabditis elegans in environmental samples. It is used in the study of the nematode's response to fungal infection. Full understanding of this bi-partite interaction requires knowledge of the pathogen's genome, analysis of its gene expression program and a capacity for genetic engineering. The acquisition of all three is reported here. A phylogenetic analysis placed D. coniospora close to the truffle parasite Tolypocladium ophioglossoides, and Hirsutella minnesotensis, another nematophagous fungus. Ascomycete nematopathogenicity is polyphyletic; D. coniospora represents a branch that has not been molecularly characterized. A detailed in silico functional analysis, comparing D. coniospora to 11 fungal species, revealed genes and gene families potentially involved in virulence and showed it to be a highly specialized pathogen. A targeted comparison with nematophagous fungi highlighted D. coniospora-specific genes and a core set of genes associated with nematode parasitism. A comparative gene expression analysis of samples from fungal spores and mycelia, and infected C. elegans, gave a molecular view of the different stages of the D. coniospora lifecycle. Transformation of D. coniospora allowed targeted gene knock-out and the production of fungus that expresses fluorescent reporter genes. It also permitted the initial characterisation of a potential fungal counter-defensive strategy, involving interference with a host antimicrobial mechanism. This high-quality annotated genome for D. coniospora gives insights into the evolution and virulence of nematode-destroying fungi. Coupled with genetic transformation, it opens the way for molecular dissection of D. coniospora physiology, and will allow both sides of the interaction between D. coniospora and C. elegans, as well as the evolutionary arms race that exists between pathogen and host, to be studied.
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