Developing context-specific next-generation sequencing policy.

Margaret Ann Curnutte, Karen L Frumovitz, Juli M Bollinger, Robert M Cook-Deegan, Amy L McGuire, Mary A Majumder

Abstract read

In one paragraph

Article in Nature biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The Bermuda Triangle: The Pragmatics, Policies, and Principles for Data Sharing in the History of the Human Genome Project.Journal of the history of biology · 2018
Article
Payer coverage policies for multigene tests.Nature biotechnology · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margaret Ann CurnutteBaylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, Texas, USA.

Karen L FrumovitzBaylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, Texas, USA.

Juli M BollingerBerman Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-6850-8562

Robert M Cook-DeeganSanford School of Public Policy, Duke University, Durham, North Carolina, USA.

Amy L McGuireBaylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, Texas, USA.

Mary A MajumderBaylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, Texas, USA.

Funding

Clinical Integration of Whole Genome Sequencing: A Policy AnalysisR01HG006460 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI MCGUIRE, AMY L · 2012 to 2015

$1.8M

NHGRI NIH HHS R01 HG006460

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chromosome MappingGenetic TestingHigh-Throughput Nucleotide SequencingPublic PolicySequence Analysis, DNAUnited StatesUnited States Food and Drug Administration

Identifiers

PMID27153269

DOI10.1038/nbt.3545

PMCPMC5117622

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.