Evidence map›Paper›PMID 27153245›Full record

ArticleJournal of cellular biochemistry2016

Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G

Eunsohl Lee, Ann M Decker, Frank C Cackowski, Lulia A Kana, Kenji Yumoto, Younghun Jung, Jingcheng Wang, Laura Buttitta, Todd M Morgan, Russell S Taichman

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Novel Techniques to Study the Bone-Tumor Microenvironment.Advances in experimental medicine and biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Eunsohl LeeDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Ann M DeckerDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Frank C CackowskiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Lulia A KanaDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Kenji YumotoDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Younghun JungDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Jingcheng WangDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan.
Laura ButtittaDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109, Michigan.
Todd M MorganDepartment of Urology, University of Michigan School of Medicine, Ann Arbor, 48109, Michigan.
Russell S TaichmanDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, 48109, Michigan. rtaich@umich.edu.
University of Michigan · US

Funding

Tumor microvesicle-mediated modulation of the bone microenvironmentP01CA093900 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KELLER, EVAN T · 2004 to 2024
$29.6M
Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Mechanisms That Regulate Dormancy of Disseminated Tumor Cells in the Bone MarrowU54CA163124 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHIOZAWA, YUSUKE · 2011 to 2015
$3.0M
NCI NIH HHS P01 CA093900NCI NIH HHS U54 CA163124NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

Prostate cancer (PCa) is known to develop resistance to chemotherapy. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers. Here, we explored how GAS6 regulates the cell cycle and apoptosis of PCa cells in response to chemotherapy. We found that GAS6 is sufficient to significantly increase the fraction of cells in G

Indexed as

AnimalsAntineoplastic AgentsApoptosisBlotting, WesternBone MarrowCell Cycle ProteinsCell ProliferationCells, CulturedDocetaxelG1 PhaseGrowth Arrest-Specific Protein 6HumansIntercellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutAntineoplastic AgentsCell Cycle ProteinsDocetaxelGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and ProteinsRNA, MessengerTaxoidsAPOPTOTIC PATHWAYBONE MARROWDOCETAXELG1 ARREST/S PHASE DELAYGAS6PROSTATE CANCER

Identifiers

PMID27153245
PMCPMC5223280
OpenAlexW2380352445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.