ArticleBiosensors2016
Real-Time Detection of Staphylococcus Aureus Using Whispering Gallery Mode Optical Microdisks.
Article in Biosensors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Liquid Crystal Microcavity Biosensors for Real-Time Liver Injury Monitoring via Whispering Gallery Mode Laser.Research (Washington, D.C.) · 2025Article
- High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis.Biomicrofluidics · 2024Review
- Whispering-Gallery Mode Optoplasmonic Microcavities: From Advanced Single-Molecule Sensors and Microlasers to Applications in Synthetic Biology.ACS photonics · 2024Review
- Spatial Multiplexing of Whispering Gallery Mode Sensors.Sensors (Basel, Switzerland) · 2023Article
- Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance.International journal of molecular sciences · 2021Review
- Label-Free Optical Resonator-Based Biosensors.Sensors (Basel, Switzerland) · 2020Review
- Whispering-Gallery Sensors.Matter · 2020Review
- FDTD Simulation: Simultaneous Measurement of the Refractive Index and the Pressure Using Microdisk Resonator with Two Whispering-Gallery Modes.Sensors (Basel, Switzerland) · 2020Article
- Bacterial Concentration Detection using a PCB-based Contactless Conductivity Sensor.Micromachines · 2019Article
- Whispering-Gallery Mode Resonators for Detecting Cancer.Sensors (Basel, Switzerland) · 2017Review
- Label-Free Biological and Chemical Sensing Using Whispering Gallery Mode Optical Resonators: Past, Present, and Future.Sensors (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whispering Gallery Mode (WGM) microresonators have recently been studied as a means to achieve real-time label-free detection of biological targets such as virus particles, specific DNA sequences, or proteins. Due to their high quality (Q) factors, WGM resonators can be highly sensitive. A biosensor also needs to be selective, requiring proper functionalization of its surface with the appropriate ligand that will attach the biomolecule of interest. In this paper, WGM microdisks are used as biosensors for detection of Staphylococcus aureus. The microdisks are functionalized with LysK, a phage protein specific for staphylococci at the genus level. A binding event on the surface shifts the resonance peak of the microdisk resonator towards longer wavelengths. This reactive shift can be used to estimate the surface density of bacteria that bind to the surface of the resonator. The limit of detection of a microdisk with a Q-factor around 10⁴ is on the order of 5 pg/mL, corresponding to 20 cells. No binding of Escherichia coli to the resonators is seen, supporting the specificity of the functionalization scheme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.