ArticleInvestigative ophthalmology & visual science2016
Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Rod Pathway Dysfunction in Early-Stage Diabetic Retinopathy Assessed by ERG and Pupillometry.Investigative ophthalmology & visual science · 2026Article
- A rapid pupillometry protocol for clinical use: effect of age and test-retest repeatability.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- A rapid pupillometry protocol for clinical use: Effect of age and test-retest repeatability.Research square · 2025Article
- Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions.Frontiers in cellular neuroscience · 2025Article
- PupilMetrics: a support system for preprocessing of pupillometric data and extraction of outcome measures.Scientific reports · 2024Article
- Congenital microcoria deletion in mouse links Sox21 dysregulation to disease and suggests a role for TGFB2 in glaucoma and myopia.American journal of human genetics · 2024Article
- Divergent outer retinal circuits drive image and non-image visual behaviors.Cell reports · 2022Article
- Pupillary Light Reflex Induced by Two-Photon Vision.Investigative ophthalmology & visual science · 2021Article
- Quantification of the early pupillary dilation kinetic to assess rod and cone activity.Scientific reports · 2021Article
- Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex.International journal of molecular sciences · 2021Article
- Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris.Investigative ophthalmology & visual science · 2020Article
- Prediction accuracy of L- and M-cone based human pupil light models.Scientific reports · 2020Article
- Chromatic Pupillometry Findings in Alzheimer's Disease.Frontiers in neuroscience · 2020Article
- The flicker Pupil Light Response (fPLR).Translational vision science & technology · 2019Article
- CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity.International journal of molecular sciences · 2019Article
- The Efemp1R345W Macular Dystrophy Mutation Causes Amplified Circadian and Photophobic Responses to Light in Mice.Investigative ophthalmology & visual science · 2019Article
- Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases.Frontiers in neurology · 2019Review
- Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response.Frontiers in neurology · 2019Article
- Standards in Pupillography.Frontiers in neurology · 2019Review
- Maturation of the Pupil Light Reflex Occurs Until Adulthood in Mice.Frontiers in neurology · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to identify which aspects of the pupil light reflex are most influenced by rods and cones independently by analyzing pupil recordings from different mouse models of photoreceptor deficiency.
methodsOne-month-old wild type (WT), rodless (Rho-/-), coneless (Cnga3-/-), or photoreceptor less (Cnga3-/-; Rho-/- or Gnat1-/-) mice were subjected to brief red and blue light stimuli of increasing intensity. To describe the initial dynamic response to light, the maximal pupillary constriction amplitudes and the derivative curve of the first 3 seconds were determined. To estimate the postillumination phase, the constriction amplitude at 9.5 seconds after light termination was related to the maximal constriction amplitude.
resultsRho-/- mice showed decreased constriction amplitude but more prolonged pupilloconstriction to all blue and red light stimuli compared to wild type mice. Cnga3-/- mice had constriction amplitudes similar to WT however following maximal constriction, the early and rapid dilation to low intensity blue light was decreased. To high intensity blue light, the Cnga3-/- mice demonstrated marked prolongation of the pupillary constriction. Cnga3-/-; Rho-/- mice had no pupil response to red light of low and medium intensity.
conclusionsFrom specific gene defective mouse models which selectively voided the rod or cone function, we determined that mouse rod photoreceptors are highly contributing to the pupil response to blue light stimuli but also to low and medium red stimuli. We also observed that cone cells mainly drive the partial rapid dilation of the initial response to low blue light stimuli. Thus photoreceptor dysfunction can be derived from chromatic pupillometry in mouse models.
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