ArticlePain2016
Pain sensitivity profiles in patients with advanced knee osteoarthritis.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 84 citations in OpenAlex.
- Effect of single end-range and not end-range Maitland mobilization on pressure pain threshold and functional measures in knee osteoarthritis: randomised, controlled clinical trial.European journal of physical and rehabilitation medicine · 2022Trial
- End-range Maitland mobilization decreasing pain sensitivity in knee osteoarthritis: randomized, controlled clinical trial.European journal of physical and rehabilitation medicine · 2022Trial
- Assessing the translational value of animal models in developing pain-targeting therapies for clinical osteoarthritis.Communications medicine · 2026Review
- The role of biopsychosocial factors in classifying pain intensity across various chronic pain conditions.Scientific reports · 2026Article
- Experimental Pain Phenotypes in Individuals With Symptomatic Knee Osteoarthritis: A Neural Network-Based Clustering Approach.Pain research & management · 2026Article
- Personalizing the Management of Knee Osteoarthritis.SMART-MD journal of precision medicine · 2026Article
- Article
- Latent transition analysis of pain phenotypes in people at risk of knee osteoarthritis: The MOST cohort study.Osteoarthritis and cartilage · 2025Article
- The causal role of brain circuits in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Relation of pain sensitization to knee loading during walking in people with knee osteoarthritis.Osteoarthritis and cartilage · 2025Article
- Terminologies and definitions used to classify patients with osteoarthritis: a scoping review.BMC rheumatology · 2025Article
- Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping.Drugs & aging · 2025Review
- Intra-Rater Reliability of Pressure Pain Threshold with Different Algometers in Healthy Participants.Muscles (Basel, Switzerland) · 2025Article
- Application value of the vertical and horizontal hierarchical responsibility management nursing model in patients undergoing appendectomy.Frontiers in surgery · 2025Article
- Multisensory sensitivity in relation to pain: a scoping review of terminology and assessment.Pain reports · 2024Article
- A multi-modal evaluation of experimental pain and psychological function in women with carpometacarpal osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Indication for spinal sensitization in chronic low back pain: mechanical hyperalgesia adjacent to but not within the most painful body area.Pain reports · 2024Article
- Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications.Rheumatology international · 2024Review
- Pain-phenotyping in osteoarthritis: Current concepts, evidence, and considerations towards a comprehensive framework for assessment and treatment.Osteoarthritis and cartilage open · 2024Review
- Phenotypes of osteoarthritis-related knee pain and their transition over time: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The development of patient profiles to subgroup individuals on a variety of variables has gained attention as a potential means to better inform clinical decision making. Patterns of pain sensitivity response specific to quantitative sensory testing (QST) modality have been demonstrated in healthy subjects. It has not been determined whether these patterns persist in a knee osteoarthritis population. In a sample of 218 participants, 19 QST measures along with pain, psychological factors, self-reported function, and quality of life were assessed before total knee arthroplasty. Component analysis was used to identify commonalities across the 19 QST assessments to produce standardized pain sensitivity factors. Cluster analysis then grouped individuals who exhibited similar patterns of standardized pain sensitivity component scores. The QST resulted in 4 pain sensitivity components: heat, punctate, temporal summation, and pressure. Cluster analysis resulted in 5 pain sensitivity profiles: a "low pressure pain" group, an "average pain" group, and 3 "high pain" sensitivity groups who were sensitive to different modalities (punctate, heat, and temporal summation). Pain and function differed between pain sensitivity profiles, along with sex distribution; however, no differences in osteoarthritis grade, medication use, or psychological traits were found. Residualizing QST data by age and sex resulted in similar components and pain sensitivity profiles. Furthermore, these profiles are surprisingly similar to those reported in healthy populations, which suggests that individual differences in pain sensitivity are a robust finding even in an older population with significant disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.