ArticlePLoS genetics2016
A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Temporal neuronal differentiation programs safeguard neuronal diversity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cell numbers contribute to cell fate during Ciona cardiopharyngeal mesoderm specification.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- β-catenin-driven endomesoderm specification is a Bilateria-specific novelty.Nature communications · 2025Article
- Cellular remodeling and JAK inhibition promote zygotic gene expression in the Ciona germline.EMBO reports · 2024Article
- Article
- Ascidian gene regulation and bioadhesion.Genesis (New York, N.Y. : 2000) · 2023Article
- A digital twin reproducing gene regulatory network dynamics of early Ciona embryos indicates robust buffers in the network.PLoS genetics · 2023Article
- BMP signaling is required to form the anterior neural plate border in ascidian embryos.Development genes and evolution · 2023Article
- An FGF timer for zygotic genome activation.Genes & development · 2023Article
- Conditional specification of endomesoderm.Cells & development · 2021Review
- The gene regulatory system for specifying germ layers in early embryos of the simple chordate.Science advances · 2021Article
- Using linkage logic theory to control dynamics of a gene regulatory network of a chordate embryo.Scientific reports · 2021Article
- Quantitative Dissection of the ProximalFrontiers in cell and developmental biology · 2021Article
- Multiple inputs into a posterior-specific regulatory network in the Ciona notochord.Developmental biology · 2019Article
- Delineating species in the speciation continuum: A proposal.Evolutionary applications · 2019Review
- Antero-posterior ectoderm patterning by canonical Wnt signaling during ascidian development.PLoS genetics · 2019Article
- Review
- Efficient genome editing using CRISPR-Cas-mediated homology directed repair in the ascidian Ciona robusta.Genesis (New York, N.Y. : 2000) · 2018Article
- Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018Review
- Depletion of Maternal Cyclin B3 Contributes to Zygotic Genome Activation in the Ciona Embryo.Current biology : CB · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal factors initiate the zygotic developmental program in animal embryos. In embryos of the chordate, Ciona intestinalis, three maternal factors-Gata.a, β-catenin, and Zic-r.a-are required to establish three domains of gene expression at the 16-cell stage; the animal hemisphere, vegetal hemisphere, and posterior vegetal domains. Here, we show how the maternal factors establish these domains. First, only β-catenin and its effector transcription factor, Tcf7, are required to establish the vegetal hemisphere domain. Second, genes specifically expressed in the posterior vegetal domain have additional repressive cis-elements that antagonize the activity of β-catenin/Tcf7. This antagonizing activity is suppressed by Zic-r.a, which is specifically localized in the posterior vegetal domain and binds to DNA indirectly through the interaction with Tcf7. Third, Gata.a directs specific gene expression in the animal hemisphere domain, because β-catenin/Tcf7 weakens the Gata.a-binding activity for target sites through a physical interaction in the vegetal cells. Thus, repressive regulation through protein-protein interactions among the maternal transcription factors is essential to establish the first distinct domains of gene expression in the chordate embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.