ReviewAnnals of the New York Academy of Sciences2016
Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1.
Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Water addition to e-liquids to reduce flavour aldehyde acetal formation: chemistry and user sensory experience and appeal.Tobacco control · 2026Article
- Extracellular Matrix-Derived Matrikines: Circulating Peptides as Candidate Mediators of Lung-to-Brain Signaling.International journal of molecular sciences · 2026Review
- Impact of Climate Change and Air Pollution on Bronchiolitis: A Narrative Review Bridging Environmental and Clinical Insights.Pathogens (Basel, Switzerland) · 2025Review
- Association Between Area-Level Deprivation and Cardio-Metabolic Risk Factors Among the Adult Population in Russia.International journal of environmental research and public health · 2025Article
- Exposure to Volatile Organic Compounds and Blood Pressure in NHANES 2011 to 2018.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Urinary Volatile Organic Compound Metabolites are Associated with High Blood Pressure Among Non-smoking Participants in the National Health and Nutrition Examination Survey (2011-2018).medRxiv : the preprint server for health sciences · 2024Article
- Impact of Wildfires on Cardiovascular Health.Circulation research · 2024Review
- Countermeasures against Pulmonary Threat Agents.The Journal of pharmacology and experimental therapeutics · 2024Review
- Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets.Frontiers in physiology · 2024Review
- Unveiling the role of TRPA1 in cardiovascular health and disease: a mini review.Frontiers in cardiovascular medicine · 2024Review
- Exposure to Volatile Organic Compounds Is Associated with Hypertension in Black Adults: The Jackson Heart Study.Environmental research · 2023Article
- Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.Environmental research · 2021Article
- Cardiovascular health impacts of wildfire smoke exposure.Particle and fibre toxicology · 2021Review
- Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.Annals of the New York Academy of Sciences · 2020Article
- Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1.Toxicology and applied pharmacology · 2020Article
- Understanding the Functional Impact of VOC-Ozone Mixtures on the Chemistry of RNA in Epithelial Lung Cells.Research report (Health Effects Institute) · 2020Article
- Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1).Toxicology and applied pharmacology · 2020Article
- The effects of hookah/waterpipe smoking on general health and the cardiovascular system.Environmental health and preventive medicine · 2019Review
- Is TRPA1International journal of molecular sciences · 2019Review
- TRPA1 channel contributes to myocardial ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Inhalation of high-level volatile aldehydes, as present in smoke from wildfires and in tobacco smoke, is associated with both acute and chronic cardiopulmonary morbidity and mortality, but the underlying mechanisms are unclear. The transient receptor potential ankyrin 1 (TRPA1) protein forms a cation channel (irritant receptor) that mediates tobacco smoke-induced airway and lung injury, yet the role of TRPA1 in the cardiovascular toxicity of aldehyde exposure is unclear. Physiologically, airway-located TRPA1 activation triggers an irritant response (e.g., coughing and "respiratory braking") that alters the rate and depth of breathing to reduce exposure. Acrolein (2-propenal), a volatile, unsaturated aldehyde, activates TRPA1. Acrolein was used as a chemical weapon in World War I and is present at high levels in wildfires and tobacco smoke. Acrolein is thought to contribute to pulmonary and cardiovascular injury caused by tobacco smoke exposure, although the role of TRPA1 in cardiovascular toxicity is unclear. This minireview addresses this gap in our knowledge by exploring literature and recent data indicating a connection between TRPA1 and cardiovascular as well as pulmonary injury due to inhaled aldehydes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.