Evidence map›Paper›PMID 27152255›Full record

ReviewWorld journal of critical care medicine2016

Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review.

Vasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. [Clinical study of prone positioning in invasive respiratory support for neonatal respiratory distress syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Trial
  4. [Effect of prone positioning on respiratory function in very preterm infants undergoing mechanical ventilation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Trial
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  14. Changes in Driving Pressure vs Oxygenation as Predictor of Mortality in Moderate to Severe Acute Respiratory Distress Syndrome Patients Receiving Prone Position Ventilation.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  15. Article
  16. Effect of COVID-19 on the incidence of postintubation laryngeal lesions.Proceedings (Baylor University. Medical Center) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vasilios KoulourasVasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos, Intensive Care Unit, University Hospital of Ioannina, 45500 Ioannina, Greece.
Georgios PapathanakosVasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos, Intensive Care Unit, University Hospital of Ioannina, 45500 Ioannina, Greece.
Athanasios PapathanasiouVasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos, Intensive Care Unit, University Hospital of Ioannina, 45500 Ioannina, Greece.
Georgios NakosVasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos, Intensive Care Unit, University Hospital of Ioannina, 45500 Ioannina, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a syndrome with heterogeneous underlying pathological processes. It represents a common clinical problem in intensive care unit patients and it is characterized by high mortality. The mainstay of treatment for ARDS is lung protective ventilation with low tidal volumes and positive end-expiratory pressure sufficient for alveolar recruitment. Prone positioning is a supplementary strategy available in managing patients with ARDS. It was first described 40 years ago and it proves to be in alignment with two major ARDS pathophysiological lung models; the "sponge lung" - and the "shape matching" -model. Current evidence strongly supports that prone positioning has beneficial effects on gas exchange, respiratory mechanics, lung protection and hemodynamics as it redistributes transpulmonary pressure, stress and strain throughout the lung and unloads the right ventricle. The factors that individually influence the time course of alveolar recruitment and the improvement in oxygenation during prone positioning have not been well characterized. Although patients' response to prone positioning is quite variable and hard to predict, large randomized trials and recent meta-analyses show that prone position in conjunction with a lung-protective strategy, when performed early and in sufficient duration, may improve survival in patients with ARDS. This pathophysiology-based review and recent clinical evidence strongly support the use of prone positioning in the early management of severe ARDS systematically and not as a rescue maneuver or a last-ditch effort.

Indexed as

Acute respiratory distress syndromeMechanical ventilationPathophysiologyProne positionVentilator-induced lung injury

Identifiers

PMID27152255
PMCPMC4848155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.