Evidence map›Paper›PMID 27152252›Full record

ArticleCurrent molecular biology reports2016

PTH Signaling and Epigenetic Control of Bone Remodeling.

Florante Ricarte, Teruyo Nakatani, Nicola Partridge

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current molecular biology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Florante RicarteNew York University School of Medicine, Sackler Institute of Graduate Biomedical Sciences, Department of Biochemistry and Molecular Pharmacology, New York, NY 10016.
Teruyo NakataniNew York University College of Dentistry, Department of Basic Science and Craniofacial Biology, New York, NY 10010.
Nicola PartridgeNew York University School of Medicine, Sackler Institute of Graduate Biomedical Sciences, Department of Biochemistry and Molecular Pharmacology, New York, NY 10016; New York University College of Dentistry, Department of Basic Science and Craniofacial Biology, New York, NY 10010.
New York University · US

Funding

Nuclear Events in PTHR1 Action on BoneR01DK047420 · NIDDK · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Nicola C Partridge · 1994 to 2026
$8.0M
Training in Pharmacological SciencesT32GM066704 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2004 to 2018
$2.6M
NIDDK NIH HHS R01 DK047420NIGMS NIH HHS T32 GM066704
6 · The paper itself

Abstract

As our understanding of the mechanisms that govern bone development advance, the role of epigenetic modifications in these processes become increasingly evident. Interestingly, in parathyroid hormone (PTH)-induced bone metabolism and remodeling, recent evidence shows that PTH signaling employs a particular facet of the epigenetic machinery to elicit its desired effects. In this review, we briefly discuss the known epigenetic events occurring in cells of the osteoblast lineage. More specifically, we elaborate on current findings that reveal the utilization of histone deacetylating enzymes (HDACs) in PTH-regulated modulation of gene expression in bone.

Indexed as

bone remodelingHDACPTHtranscriptional regulation

Identifiers

PMID27152252
PMCPMC4853160
OpenAlexW2342256732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.