Evidence map›Paper›PMID 27152133›Full record

ArticleStandards in genomic sciences2016

Complete genome sequence of an agr-dysfunctional variant of the ST239 lineage of the methicillin-resistant Staphylococcus aureus strain GV69 from Brazil.

Ana M N Botelho, Maiana O C Costa, Cristiana O Beltrame, Fabienne A Ferreira, Marina F Côrtes, Paula T Bandeira, Nicholas C B Lima, Rangel C Souza, Luiz G P Almeida, Ana T R Vasconcelos and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Standards in genomic sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Survival Strategies ofAntibiotics (Basel, Switzerland) · 2024
    Article
  2. Review
  3. Chemokine production induced by Corynebacterium pseudotuberculosis in a murine model.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana M N Botelho *Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
Maiana O C Costa *Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Cristiana O BeltrameLaboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
Fabienne A FerreiraLaboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
Marina F CôrtesLaboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
Paula T BandeiraLaboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
Nicholas C B LimaLaboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Rangel C SouzaLaboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Luiz G P AlmeidaLaboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Ana T R VasconcelosLaboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Marisa F NicolásLaboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Agnes M S FigueiredoLaboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is a versatile Gram-positive coccus frequently found colonizing the skin and nasal membranes of humans. The acquisition of the staphylococcal cassette chromosome mec was a major milestone in the evolutionary path of methicillin-resistant S. aureus. This genetic element carries the mecA gene, the main determinant of methicillin resistance. MRSA is involved in a plethora of opportunistic infectious diseases. The accessory gene regulator is the major S. aureus quorum sensing system, playing an important role in staphylococcal virulence, including the development of biofilms. We report the complete genome sequence (NCBI BioProject ID: PRJNA264181) of the methicillin-resistant S. aureus strain GV69 (= CMVRS P4521), a variant of the ST239 lineage that presents with a natural attenuation of agr-RNAIII transcription and a moderate accumulation of biofilm.

Indexed as

agr dysfunctionComplete genome sequenceMethicillin-resistant Staphylococcus aureusSkin hospital infectionST239

Identifiers

PMID27152133
PMCPMC4857242

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.