ArticleThe journal of venomous animals and toxins including tropical diseases2016
Initial peptidomic profiling of Brazilian sea urchins: Arbacia lixula, Lytechinus variegatus and Echinometra lucunter.
Article in The journal of venomous animals and toxins including tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Prickly Defenders: A Review of Venomous Sea Urchins (Echinoidea).Marine drugs · 2025Review
- Exploring the Potential of Peptides Derived from the Coelomic Fluid ofF1000Research · 2025Article
- In silico analysis ofNarra J · 2024Article
- Article
- Design,Frontiers in pharmacology · 2023Article
- Caspase-1 and Cathepsin B Inhibitors from Marine Invertebrates, Aiming at a Reduction in Neuroinflammation.Marine drugs · 2022Article
- Neglected Venomous Animals and Toxins: Underrated Biotechnological Tools in Drug Development.Toxins · 2021Review
- Preliminary molecular characterization of a proinflammatory and nociceptive molecule from theThe journal of venomous animals and toxins including tropical diseases · 2017Article
- Discovery of bioactive peptides fromJournal of advanced pharmaceutical technology & researchArticle
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4 authors.
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Abstract
backgroundSea urchins can be found throughout the Brazilian coast and are reported to be one of the major causes of marine accidents on the shoreline. Although not lethal, these accidents are reported to be extremely painful. In order to understand the toxinology of the Brazilian urchins, a peptidomic approach was performed aiming to characterize the naturally occurring peptides in both the coelomic fluid and the spine.
methodsAnimals were collected without gender distinction and samples of the coelomic fluid and spines extracted were analyzed by RP-HPLC and mass spectrometry for peptide de novo sequencing.
resultsSeveral peptides were identified either in the coelomic fluid or the spine extract (except for E. lucunter). The peptide sequences were aligned with public deposited sequences and possible functions were inferred. Moreover, some peptides can be cryptides, since their sequences were identified within functional proteins, for example thymosin from Strongylocentrotus purpuratus.
conclusionsAlthough preliminary, the peptidomic approach presented here reports, for the first time, the abundance of novel biological molecules derived from these animals. The discovery of such molecules may be of potential biotechnological application, as described for other organisms; nevertheless, further studies are required.
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