Clinical presentation and management of suspected ribavirin toxicosis in a dog.

Kimberly Bridges, Nicole Beckel, Claire Sharp, Laura Stern

Abstract read

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Model based approach for estimating the dosage regimen of indomethacin a potential antiviral treatment of patients infected with SARS CoV-2.Journal of pharmacokinetics and pharmacodynamics · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kimberly BridgesNew England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).

Nicole BeckelNew England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).

Claire SharpNew England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).

Laura SternNew England Animal Medical Center, 595 West Center Street, West Bridgewater, Massachusetts 02379, USA (Bridges, Beckel); Small Animal Emergency and Critical Care, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Sharp); ASPCA Animal Poison Control Center, 1717 S. Philo Road, Suite 36, Urbana, Illinois 61802, USA (Stern).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 5-month-old pit bull terrier was presented for evaluation of progressive lethargy, vomiting, diarrhea, and anorexia 45 hours after ingestion of 625 mg/kg body weight (BW) (9000 mg) of the antiviral medication, ribavirin. Abnormalities that were detected included dehydration, tachycardia, elevated liver enzymes, and prolonged prothrombin time. The dog was discharged after 5 days of aggressive supportive care consisting of intravenous fluids, antiemetics, gastroprotectants, hepatoprotectants, dextrose supplementation, and vitamin B/K1 supplementation.

Indexed as

AnimalsAntiviral AgentsChemical and Drug Induced Liver InjuryDog DiseasesDogsFemaleGastrointestinal DiseasesRibavirinAntiviral AgentsRibavirin

Identifiers

PMID27152039

PMCPMC4827742

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.