ArticleThe Plant cell2016
Dual and Opposing Roles of Xanthine Dehydrogenase in Defense-Associated Reactive Oxygen Species Metabolism in Arabidopsis.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 127 citations in OpenAlex.
- Mechanism of Elevated COFoods (Basel, Switzerland) · 2026Article
- Exl1 from Pectobacterium activates a jasmonate-dependent immune network in Arabidopsis thaliana.Plant molecular biology · 2026Article
- Genetic resistance to vector-borne hemoprotozoa in livestock: molecular markers, host-parasite interactions, and implications for breeding and control.Journal of veterinary science · 2025Review
- XDH-1 inactivation causes xanthine stone formation in Caenorhabditis elegans which is inhibited by SULP-4-mediated anion exchange in the excretory cell.PLoS biology · 2025Article
- XDH-1 inactivation causes xanthine stone formation inbioRxiv : the preprint server for biology · 2025Article
- Research on the Expression of Immune-Related Genes at Different Stages in the Third-Instar Larvae ofInsects · 2025Article
- Transcriptomic and metabolomic profiling of the potato plant response to zebra chip disease.PloS one · 2025Article
- ROS, an Important Plant Growth Regulator in Root Growth and Development: Functional Genes and Mechanism.Biology · 2024Review
- Regulation of bacterial virulence genes by PecS family transcription factors.Journal of bacteriology · 2024Review
- ROS-mediated thylakoid membrane remodeling and triacylglycerol biosynthesis under nitrogen starvation in the algaFrontiers in plant science · 2024Article
- Integrated transcriptomics, metabolomics and physiological analyses reveal differential response mechanisms of wheat to cadmium and/or salinity stress.Frontiers in plant science · 2024Article
- Unveiling the role of epigenetic mechanisms and redox signaling in alleviating multiple abiotic stress in plants.Frontiers in plant science · 2024Review
- Nanobiotechnology-mediated regulation of reactive oxygen species homeostasis under heat and drought stress in plants.Frontiers in plant science · 2024Review
- The Mechanisms of Molybdate Distribution and Homeostasis with Special Focus on the Model PlantMolecules (Basel, Switzerland) · 2023Review
- PacBio Full-Length Transcriptome Sequencing Reveals the Mechanism of Salt Stress Response inPlants (Basel, Switzerland) · 2023Article
- Transcription Factor PecS MediatesJournal of bacteriology · 2023Article
- A chromosome-level genome assembly for Erianthus fulvus provides insights into its biofuel potential and facilitates breeding for improvement of sugarcane.Plant communications · 2023Article
- Article
- A recessive gene Cmpmr2F confers powdery mildew resistance in melon (Cucumis melo L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- The Global Regulator MftR Controls Virulence and Siderophore Production in Burkholderia thailandensis.Journal of bacteriology · 2022Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While plants produce reactive oxygen species (ROS) for stress signaling and pathogen defense, they need to remove excessive ROS induced during stress responses in order to minimize oxidative damage. How can plants fine-tune this balance and meet such conflicting needs? Here, we show that XANTHINE DEHYDROGENASE1 (XDH1) in Arabidopsis thaliana appears to play spatially opposite roles to serve this purpose. Through a large-scale genetic screen, we identified three missense mutations in XDH1 that impair XDH1's enzymatic functions and consequently affect the powdery mildew resistance mediated by RESISTANCE TO POWDERY MILDEW8 (RPW8) in epidermal cells and formation of xanthine-enriched autofluorescent objects in mesophyll cells. Further analyses revealed that in leaf epidermal cells, XDH1 likely functions as an oxidase, along with the NADPH oxidases RbohD and RbohF, to generate superoxide, which is dismutated into H2O2 The resulting enrichment of H2O2 in the fungal haustorial complex within infected epidermal cells helps to constrain the haustorium, thereby contributing to RPW8-dependent and RPW8-independent powdery mildew resistance. By contrast, in leaf mesophyll cells, XDH1 carries out xanthine dehydrogenase activity to produce uric acid in local and systemic tissues to scavenge H2O2 from stressed chloroplasts, thereby protecting plants from stress-induced oxidative damage. Thus, XDH1 plays spatially specified dual and opposing roles in modulation of ROS metabolism during defense responses in Arabidopsis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.