Evidence map›Paper›PMID 27151940›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016

Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats.

John H Winston, Sushil K Sarna

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Neuromodulation for functional upper gastrointestinal diseases.Gut microbiota and integrative wellness · 2023
    Article
  6. Article
  7. Article
  8. Article
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  16. Article
  17. Choosing an Animal Model for the Study of Functional Dyspepsia.Canadian journal of gastroenterology & hepatology · 2018
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John H WinstonDivision of Gastroenterology, Department of Internal Medicine Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Galveston, Texas; and.
Sushil K SarnaDivision of Gastroenterology, Department of Internal Medicine Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Galveston, Texas; and Department of Neuroscience and Cell Biology Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Galveston, Texas sksarna@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Developmental Origins of Functional DyspepsiaR01DK088796 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SARNA, SUSHIL K · 2011 to 2014
$1.4M
NIDDK NIH HHS R01 DK088796
6 · The paper itself

Abstract

Gastric hypersensitivity (GHS) and anxiety are prevalent in functional dyspepsia patients; their underlying mechanisms remain unknown largely because of lack of availability of live visceral tissues from human subjects. Recently, we demonstrated in a preclinical model that rats subjected to neonatal colon inflammation show increased basal plasma norepinephrine (NE), which contributes to GHS through the upregulation of nerve growth factor (NGF) expression in the gastric fundus. We tested the hypothesis that neonatal colon inflammation increases anxiety-like behavior and sympathetic nervous system activity, which upregulates the expression of NGF to induce GHS in adult life. Chemical sympathectomy, but not adrenalectomy, suppressed the elevated NGF expression in the fundus muscularis externa and GHS. The measurement of heart rate variability showed a significant increase in the low frequency-to-high frequency ratio in GHS vs. the control rats. Stimulus-evoked release of NE from the fundus muscularis externa strips was significantly greater in GHS than in the control rats. Tyrosine hydroxylase expression was increased in the celiac ganglia of the GHS vs. the control rats. We found an increase in trait but not stress-induced anxiety-like behavior in GHS rats in an elevated plus maze. We concluded that neonatal programming triggered by colon inflammation upregulates tyrosine hydroxylase in the celiac ganglia, which upregulates the release of NE in the gastric fundus muscularis externa. The increase of NE release from the sympathetic nerve terminals concentration dependently upregulates NGF, which proportionately increases the visceromotor response to gastric distention. Neonatal programming concurrently increases anxiety-like behavior in GHS rats.

Indexed as

Abdominal PainAge FactorsAnimalsAnimals, NewbornAnxietyBehavior, AnimalColitisColonDisease Models, AnimalHyperalgesiaMaleMechanotransduction, CellularNerve Growth FactorNorepinephrinePressureRats, Sprague-DawleyNerve Growth FactorNorepinephrineTyrosine 3-Monooxygenasefunctional dyspepsianerve growth factornorepinephrinevisceral hypersensitivity

Identifiers

PMID27151940
PMCPMC4967178
OpenAlexW2345450344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.