Evidence map›Paper›PMID 27151921›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion.

Anne Sinning, Nikita Radionov, Francesco Trepiccione, Karen I López-Cayuqueo, Maximilien Jayat, Stéphanie Baron, Nicolas Cornière, R Todd Alexander, Juliette Hadchouel, Dominique Eladari and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Pendrin: linking acid base to blood pressure.Pflugers Archiv : European journal of physiology · 2024
    Review
  4. The role of NaPflugers Archiv : European journal of physiology · 2024
    Review
  5. Article
  6. The K-Cl cotransporter-3 in the mammalian kidney.Current opinion in nephrology and hypertension · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Control of sodium and potassium homeostasis by renal distal convoluted tubules.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  12. Pendrin-null mice develop severe hypokalemia following dietary NaAmerican journal of physiology. Renal physiology · 2022
    Article
  13. Review
  14. KCC3a, a Strong Candidate Pathway for KFrontiers in cell and developmental biology · 2022
    Article
  15. Targeting the pH Paradigm at the Bedside: A Practical Approach.International journal of molecular sciences · 2020
    Review
  16. Sex differences in solute transport along the nephrons: effects of NaAmerican journal of physiology. Renal physiology · 2020
    Article
  17. Adaptive response of the murine collecting duct to alkali loading.Pflugers Archiv : European journal of physiology · 2020
    Article
  18. Review
  19. Hyperkalemia: pathophysiology, risk factors and consequences.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Anne SinningInstitut für Humangenetik, University Hospital Jena, Friedrich Schiller Universität, Jena, Germany.
Nikita RadionovInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France.
Francesco TrepiccioneInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France.
Karen I López-CayuqueoInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France.
Maximilien JayatInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France.
Stéphanie BaronDepartment de Physiologie, Hopital Européen Georges Pompidou, Assistance Publique-Hopitaux de Paris, Paris, France.
Nicolas CornièreService de Néphrologie et Transplantation Rénale, Centre Hospitalier Universitaire de La Réunion, St. Denis, France.
R Todd AlexanderDepartments of Pediatrics and Physiology, University of Alberta, Edmonton, Alberta, Canada; and.
Juliette HadchouelInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France.
Dominique EladariInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France.
Christian A HübnerInstitut für Humangenetik, University Hospital Jena, Friedrich Schiller Universität, Jena, Germany.
Régine ChambreyInstitut National de la Santé et de la Recherche Médicale U970, Paris Cardiovascular Research Center, Paris, France; regine.chambrey@inserm.fr.
Délégation Paris 5 · FRFriedrich Schiller University Jena · DEAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Universitaire de La Réunion · FRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently described a novel thiazide-sensitive electroneutral NaCl transport mechanism resulting from the parallel operation of the Cl

Indexed as

Blood VolumeAnimalsChloride-Bicarbonate AntiportersHypokalemiaMiceMice, KnockoutUp-RegulationChloride-Bicarbonate Antiportersdiureticshypertensionhypokalemia

Identifiers

PMID27151921
PMCPMC5198265
OpenAlexW2347182223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.