Evidence map›Paper›PMID 27151913›Full record

ArticleStem cells translational medicine2016

Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure.

Udit Agarwal, Amanda W Smith, Kristin M French, Archana V Boopathy, Alex George, David Trac, Milton E Brown, Ming Shen, Rong Jiang, Janet D Fernandez and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Stem cell therapy for single ventricle congenital heart disease - current state and future directions.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Biomaterials science · 2022
    Article
  20. Encapsulation of Pediatric Cardiac-Derived C-KitMethods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Udit AgarwalWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia, USA.
Amanda W SmithWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia, USA.
Kristin M FrenchWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia, USA.
Archana V BoopathyWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia, USA.
Alex GeorgeWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA.
David TracWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA.
Milton E BrownWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia, USA.
Ming ShenDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
Rong JiangDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
Janet D FernandezDepartment of Cardiothoracic Surgery, School of Medicine, Emory University, Atlanta, Georgia, USA.
Brian E KogonChildren's Healthcare of Atlanta, Atlanta, Georgia, USA.
Kirk R KanterChildren's Healthcare of Atlanta, Atlanta, Georgia, USA.
Baahaldin AlsoufiChildren's Healthcare of Atlanta, Atlanta, Georgia, USA.
Mary B WagnerDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA.
Michael E DavisWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia, USA michael.davis@bme.emory.edu.
The Wallace H. Coulter Department of Biomedical Engineering · USEmory University · USChildren's Healthcare of Atlanta · USGeorgia Institute of Technology · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Research Trainng in Academic CardiologyT32HL007745 · NHLBI · EMORY UNIVERSITY · PI TAYLOR, WILLIAM ROBERT · 1994 to 2023
$10.6M
CPC Excosomes for Cardiac TherapyR56HL124380 · NHLBI · EMORY UNIVERSITY · PI DAVIS, MICHAEL E · 2014 to 2014
$436k
NCATS NIH HHS UL1 TR001425NHLBI NIH HHS HL124380NHLBI NIH HHS R56 HL124380NHLBI NIH HHS T32 HL007745NHLBI NIH HHS T32HL007745NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

unlabelledChildren with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups based on age: neonate (1 day to 1 month), infant (1 month to 1 year), and child (1 to 5 years). Adolescent athymic rats were subjected to sham or pulmonary artery banding surgery to generate a model of right ventricular (RV) heart failure. Two weeks after surgery, hCPCs were injected in RV musculature noninvasively. Analysis of cardiac function 4 weeks post-transplantation demonstrated significantly increased tricuspid annular plane systolic excursion and RV ejection fraction and significantly decreased wall thickness and fibrosis in rats transplanted with neonatal hCPCs compared with saline-injected rats. Computational modeling and systems biology analysis were performed on arrays and gave insights into potential mechanisms at the microRNA and gene level. Mechanisms including migration and proliferation assays, as suggested by computational modeling, showed improved chemotactic and proliferative capacity of neonatal hCPCs compared with infant/child hCPCs. In vivo immunostaining further suggested increased recruitment of stem cell antigen 1-positive cells in the right ventricle. This is the first study to assess the role of hCPC age in juvenile RV heart failure. Interestingly, the reparative potential of hCPCs is age-dependent, with neonatal hCPCs exerting the maximum beneficial effect compared with infant and child hCPCs. SIGNIFICANCE: Stem cell therapy for children with congenital heart defects is moving forward, with several completed and ongoing clinical trials. Although there are studies showing how children differ from adults, few focus on the differences among children. This study using human cardiac progenitor cells shows age-related changes in the reparative ability of cells in a model of pediatric heart failure and uses computational and systems biology to elucidate potential mechanisms.

Indexed as

Stem Cell TransplantationAdultAgingAnimalsCell ProliferationCells, CulturedChild, PreschoolHeart Defects, CongenitalHeart FailureHumansInfantInfant, NewbornMyocardiumRatsRats, NudeRats, TransgenicCell transplantationComputational biologyHeart failurePediatricsProgenitor cell

Identifiers

PMID27151913
PMCPMC4922847
OpenAlexW2346568680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.