ArticleThe Journal of cell biology1989
The expression of sarcomeric muscle-specific contractile protein genes in BC3H1 cells: BC3H1 cells resemble skeletal myoblasts that are defective for commitment to terminal differentiation.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- The Role of Embryonic Chick Muscle Cell Culture in the Study of Skeletal Myogenesis.Frontiers in physiology · 2021Review
- Lifetime Distributions from Tracking Individual BC3H1 Cells Subjected to Yessotoxin.Frontiers in bioengineering and biotechnology · 2015Article
- Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis.American journal of physiology. Cell physiology · 2012Article
- Reduced differentiation potential of primary MyoD-/- myogenic cells derived from adult skeletal muscle.The Journal of cell biology · 1999Article
- Coordinated incorporation of skeletal muscle dihydropyridine receptors and ryanodine receptors in peripheral couplings of BC3H1 cells.The Journal of cell biology · 1997Article
- Expression of MRF4, a myogenic helix-loop-helix protein, produces multiple changes in the myogenic program of BC3H-1 cells.Molecular and cellular biology · 1992Article
- Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.The Journal of clinical investigation · 1992Article
- Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.Molecular and cellular biology · 1991Article
- The ryanodine receptor/junctional channel complex is regulated by growth factors in a myogenic cell line.The Journal of cell biology · 1991Article
- Changes in the mechanism of Ca2(+) mobilization during the differentiation of BC3H1 muscle cells.The Biochemical journal · 1991Article
- MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin.The Journal of cell biology · 1990Article
- Mammalian nonsarcomeric myosin regulatory light chains are encoded by two differentially regulated and linked genes.The Journal of cell biology · 1990Article
- Translocation of the brain-type glucose transporter largely accounts for insulin stimulation of glucose transport in BC3H-1 myocytes.The Biochemical journal · 1990Article
- Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells.The Journal of cell biology · 1990Article
- Dihydropyridine receptor gene expression is regulated by inhibitors of myogenesis and is relatively insensitive to denervation.The Journal of clinical investigation · 1990Article
- Molecular cloning and characterization of the ryanodine receptor/junctional channel complex cDNA from skeletal muscle sarcoplasmic reticulum.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The BC3H1 cell line has been used widely as a model for studying regulation of muscle-related proteins, such as the acetylcholine receptor, myokinase, creatine kinase, and actin. These cells, derived from a nitrosourea-induced mouse brain neoplasm, have some of the morphological characteristics of smooth muscle and have been shown to express the vascular smooth muscle isoform of alpha-actin. To provide further information about the contractile protein phenotype of BC3H1 and to gain additional insights into the possible tissue of origin of these cells, we have examined the expression of a battery of contractile protein genes. During rapid growth, subconfluent BC3H1 cells express the nonmuscle isoform of alpha-tropomyosin (alpha-Tm) and the nonsarcomeric isoforms of myosin heavy and light chains (MHCs and MLCs, respectively), but do not express troponin T(TnT). However, when BC3H1 cells differentiate in response to incubation in serum-deprived medium or upon approaching confluence, they express TnT as well as sarcomeric muscle isoforms of MHC, MLC 2 and 3, alpha-Tm, and alpha-actin. These results suggest that BC3H1 is a skeletal muscle cell line of ectodermal origin that is defective for commitment to terminal differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.