ArticleThe Journal of cell biology1989
Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Prolonged myosin binding increases muscle stiffness in Drosophila models of Freeman-Sheldon syndrome.Biophysical journal · 2021Article
- Impaired muscle morphology in aDisease models & mechanisms · 2020Article
- Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.Skeletal muscle · 2020Article
- Developmental MYH3 Myopathy Associated with Expression of Mutant Protein and Reduced Expression Levels of Embryonic MyHC.PloS one · 2015Article
- Recessive myosin myopathy with external ophthalmoplegia associated with MYH2 mutations.European journal of human genetics : EJHG · 2014Article
- Myosinopathies: pathology and mechanisms.Acta neuropathologica · 2013Review
- Expression profiles of muscle disease-associated genes and their isoforms during differentiation of cultured human skeletal muscle cells.BMC musculoskeletal disorders · 2012Article
- Article
- Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.The Journal of cell biology · 1996Article
- Modulation of myosin filament organization by C-protein family members.Molecular biology of the cell · 1996Article
- The evolutionary relationship of avian and mammalian myosin heavy-chain genes.Journal of molecular evolution · 1993Article
- Organization of the human skeletal myosin heavy chain gene cluster.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Four sarcomeric myosin heavy chain genes are expressed by human fetal skeletal muscle cells differentiating in culture.Gene expression · 1992Article
- Structural and phylogenetic analysis of the chicken ventricular myosin heavy chain rod.Journal of molecular evolution · 1991Article
- Expression of human beta-myosin heavy chain fragments in Escherichia coli; localization of actin interfaces on cardiac myosin.Journal of muscle research and cell motility · 1990Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1990Article
- Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene.Nucleic acids research · 1989Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
We have isolated a human cDNA which corresponds to a developmentally regulated sarcomeric myosin heavy chain. RNA hybridization and DNA sequence analysis indicate that this cDNA, called SMHCP, encodes a perinatal myosin heavy chain isoform. The nucleotide and deduced amino acid sequences of the 3.4-kb cDNA insert show strong homology with other sarcomeric myosin heavy chains. The strongest homology is to a previously described 970-bp cDNA encoding a rat perinatal isoform (Periasamy, M., D. F. Wieczorek, and B. Nadal-Ginard. 1984. J. Biol. Chem. 259:13573-13578). The homology between the analogous human and rat perinatal myosin heavy chain cDNAs is maintained through the highly isoform-specific final 20 carboxyl-terminal amino acids, as well as the 3' untranslated region. Ribonuclease protection studies show that the mRNA encoding this isoform is expressed at high levels in 21-wk fetal skeletal tissue and not in fetal cardiac muscle. In contrast to the rat perinatal isoform, which was not found to be expressed in adult hind-leg tissue, the gene encoding SMHCP continues to be expressed in adult human skeletal tissue, but at lower levels relative to fetal skeletal tissue.
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