Evidence map›Paper›PMID 27151653›Full record

ReviewThe oncologist2016

A Comprehensive Look at Polypharmacy and Medication Screening Tools for the Older Cancer Patient.

Andrew M Whitman, Kathlene A DeGregory, Amy L Morris, Erika E Ramsdale

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The oncologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03283735 (Deprescribing), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03283735 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal

TypeinterventionalSponsorUniversity of Beira InteriorRan2019 to 2020Enrolled380ConditionsPolypharmacy, DeprescriptionsArmsElderly Enablement
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. The potential for deprescribing in a palliative oncology patient population: a cross-sectional study.European journal of hospital pharmacy : science and practice · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Breast cancer, placing drug interactions in the spotlight: is polypharmacy the cause of everything?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Article
  19. Use of Potentially Inappropriate Medications in Older Allogeneic Hematopoietic Cell Transplantation Recipients.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew M WhitmanDepartment of Pharmacy Services, University of Virginia Health System, Charlottesville, Virginia, USA Amw6az@virginia.edu.
Kathlene A DeGregoryDepartment of Pharmacy Services, University of Virginia Health System, Charlottesville, Virginia, USA.
Amy L MorrisDepartment of Pharmacy Services, University of Virginia Health System, Charlottesville, Virginia, USA.
Erika E RamsdaleDivision of Hematology/Oncology, University of Virginia Health System, Charlottesville, Virginia, USA.
University of Virginia Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelled: Inappropriate medication use and polypharmacy are extremely common among older adults. Numerous studies have discussed the importance of a comprehensive medication assessment in the general geriatric population. However, only a handful of studies have evaluated inappropriate medication use in the geriatric oncology patient. Almost a dozen medication screening tools exist for the older adult. Each available tool has the potential to improve aspects of the care of older cancer patients, but no single tool has been developed for this population. We extensively reviewed the literature (MEDLINE, PubMed) to evaluate and summarize the most relevant medication screening tools for older patients with cancer. Findings of this review support the use of several screening tools concurrently for the elderly patient with cancer. A deprescribing tool should be developed and included in a comprehensive geriatric oncology assessment. Finally, prospective studies are needed to evaluate such a tool to determine its feasibility and impact in older patients with cancer. IMPLICATIONS FOR PRACTICE: The prevalence of polypharmacy increases with advancing age. Older adults are more susceptible to adverse effects of medications. "Prescribing cascades" are common, whereas "deprescribing" remains uncommon; thus, older patients tend to accumulate medications over time. Older patients with cancer are at high risk for adverse drug events, in part because of the complexity and intensity of cancer treatment. Additionally, a cancer diagnosis often alters assessments of life expectancy, clinical status, and competing risk. Screening for polypharmacy and potentially inappropriate medications could reduce the risk for adverse drug events, enhance quality of life, and reduce health care spending for older cancer patients.

Indexed as

Geriatric AssessmentPolypharmacyPotentially Inappropriate Medication ListAgedHumansNeoplasmsGeriatricsOncologyPolypharmacyPotentially inappropriate medications

Identifiers

PMID27151653
PMCPMC4912369
OpenAlexW2346193237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.