ArticleBrain stimulation
Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Non-Human Primate Model of Parkinsonism.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 125 citations in OpenAlex.
- Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety.Journal of Parkinson's disease · 2026Review
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.Science advances · 2025Article
- Adaptive deep brain stimulation timed to gait phase improves walking in Parkinson's disease.medRxiv : the preprint server for health sciences · 2025Article
- Delay suppression control of β-oscillations: a proposal for dual-target adaptive deep brain stimulation on STN-GPe network model.Biological cybernetics · 2025Article
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation.NPJ Parkinson's disease · 2024Article
- Synaptic reorganization of synchronized neuronal networks with synaptic weight and structural plasticity.PLoS computational biology · 2024Article
- Simulated dataset on coordinated reset stimulation of homogeneous and inhomogeneous networks of excitatory leaky integrate-and-fire neurons with spike-timing-dependent plasticity.Data in brief · 2024Article
- Editorial: Neuromodulation using spatiotemporally complex patterns.Frontiers in neuroinformatics · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Deep brain stimulation for Parkinson's disease: bibliometric analysis of the top 100 cited literature.Frontiers in aging neuroscience · 2024Review
- Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections.Frontiers in network physiology · 2024Article
- Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease.Translational neurodegeneration · 2023Review
- Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet.Scientific reports · 2023Article
- Mean-Field Approximations With Adaptive Coupling for Networks With Spike-Timing-Dependent Plasticity.Neural computation · 2023Article
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- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram.Frontiers in neuroinformatics · 2023Review
14 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNovel deep brain stimulation (DBS) paradigms are being explored in an effort to further optimize therapeutic outcome for patients with Parkinson's disease (PD). One approach, termed 'Coordinated Reset' (CR) DBS, was developed to target pathological oscillatory network activity. with desynchronizing effects and associated therapeutic benefit hypothesized to endure beyond cessation of stimulus delivery.
objectiveTo characterize the acute and carry-over effects of low-intensity CR DBS versus traditional DBS (tDBS) in the region of the subthalamic nucleus (STN).
methodsA within-subject, block treatment design involving the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) non-human primate model of parkinsonism was used. Each treatment block consisted of five days of daily DBS delivery followed by a one week minimum post-treatment observation window. Motor behavior was quantified using a modified rating scale for both animals combined with an objective, upper-extremity reach task in one animal.
resultsBoth animals demonstrated significant motor improvements during acute tDBS; however, within-session and post-treatment carry-over was limited. Acute motor improvements were also observed in response to low-intensity CR DBS; however, both within- and between-session therapeutic carry-over enhanced progressively following each daily treatment. Moreover, in contrast to tDBS, five consecutive days of CR DBS treatment yielded carry-over benefits that persisted for up to two weeks without additional intervention. Notably, the magnitude and time-course of CR DBS' effects on each animal varied with daily dose-duration, pointing to possible interaction effects involving baseline parkinsonian severity.
conclusionOur results support the therapeutic promise of CR DBS for PD, including its potential to induce carryover while reducing both side effect risk and hardware power consumption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.