ArticleReproductive toxicology (Elmsford, N.Y.)2016
Monohaloacetic acid drinking water disinfection by-products inhibit follicle growth and steroidogenesis in mouse ovarian antral follicles in vitro.
Article in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Desalination of Seawater: Comprehensive Nontarget Assessment of Disinfection Byproducts.Environment & health (Washington, D.C.) · 2026Article
- Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men.Environment international · 2024Article
- Impacts of iodoacetic acid on reproduction: current evidence, underlying mechanisms, and future research directions.Frontiers in public health · 2024Review
- Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women.Frontiers in cell and developmental biology · 2024Review
- Associations between Urinary Concentrations of Disinfection Byproducts andEnvironmental health perspectives · 2023Article
- Effects of prenatal and lactational exposure to iodoacetic acid on the F1 generation of mice†.Biology of reproduction · 2022Article
- Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles.Journal of environmental sciences (China) · 2022Article
- Drinking Water Disinfection Byproducts, Ingested Nitrate, and Risk of Endometrial Cancer in Postmenopausal Women.Environmental health perspectives · 2022Article
- Effect of iodoacetic acid on the reproductive system of male mice.Frontiers in pharmacology · 2022Article
- Iodoacetic Acid, a Water Disinfection Byproduct, Disrupts Hypothalamic, and Pituitary Reproductive Regulatory Factors and Induces Toxicity in the Female Pituitary.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Iodoacetic acid affects estrous cyclicity, ovarian gene expression, and hormone levels in mice†.Biology of reproduction · 2021Article
- Endocrine Disruptors in Water and Their Effects on the Reproductive System.International journal of molecular sciences · 2020Review
- Iodoacetic acid inhibits follicle growth and alters expression of genes that regulate apoptosis, the cell cycle, estrogen receptors, and ovarian steroidogenesis in mouse ovarian follicles.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Exposure Characterization of Haloacetic Acids in Humans for Exposure and Risk Assessment Applications: An Exploratory Study.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Water disinfection greatly reduced the incidence of waterborne diseases, but the reaction between disinfectants and natural organic matter in water leads to the formation of drinking water disinfection by-products (DBPs). DBPs have been shown to be toxic, but their effects on the ovary are not well defined. This study tested the hypothesis that monohalogenated DBPs (chloroacetic acid, CAA; bromoacetic acid, BAA; iodoacetic acid, IAA) inhibit antral follicle growth and steroidogenesis in mouse ovarian follicles. Antral follicles were isolated and cultured with either vehicle or DBPs (0.25-1.00mM of CAA; 2-15μM of BAA or IAA) for 48 and 96h. Follicle growth was measured every 24h and the media were analyzed for estradiol levels at 96h. Exposure to DBPs significantly inhibited antral follicle growth and reduced estradiol levels compared to controls. These data demonstrate that DBP exposure caused ovarian toxicity in vitro.
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