Evidence map›Paper›PMID 27151248›Full record

ArticleThe British journal of nutrition2016

Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet.

Marco Candela, Elena Biagi, Matteo Soverini, Clarissa Consolandi, Sara Quercia, Marco Severgnini, Clelia Peano, Silvia Turroni, Simone Rampelli, Paolo Pozzilli and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03962335 (ModulAtion of Gut Microbiota Through Nutritional Interventions in Behcet's Syndrome pAtients), which is not on this map. Cited by 141 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 14 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03962335 nacompletednot on this mapstarted 2019, after this paper: background citation

ModulAtion of Gut Microbiota Through Nutritional Interventions in Behcet's Syndrome pAtients: the MAMBA Study

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria CareggiRan2019 to 2023Enrolled90ConditionsBehcet SyndromeArmsVegetarian diet, Mediterranean diet with butyrate, Mediterranean diet
3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 14 syntheses or guidelines pooled it, 265 citations in OpenAlex.

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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Marco Candela1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
Elena Biagi1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
Matteo Soverini1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
Clarissa Consolandi2Institute of Biomedical Technologies,Italian National Research Council,20090 Segrate,Milan,Italy.
Sara Quercia1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
Marco Severgnini2Institute of Biomedical Technologies,Italian National Research Council,20090 Segrate,Milan,Italy.
Clelia Peano2Institute of Biomedical Technologies,Italian National Research Council,20090 Segrate,Milan,Italy.
Silvia Turroni1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
Simone Rampelli1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
Paolo Pozzilli3Department of Endocrinology and Diabetes,University Campus Bio-Medico,00128 Rome,Italy.
Mario Pianesi4International Study Center for Environment,Agriculture, Food, Health and Economics,62029 Tolentino,Italy.
Francesco Fallucca5In Unam Sapientiam,La Sapienza University,00161 Rome,Italy.
Patrizia Brigidi1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
University of Bologna · ITNational Research Council · ITInstitute of Ecosystem Study · ITSapienza University of Rome · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota exerts a role in type 2 diabetes (T2D), and deviations from a mutualistic ecosystem layout are considered a key environmental factor contributing to the disease. Thus, the possibility of improving metabolic control in T2D by correcting gut microbiome dysbioses through diet has been evaluated. Here, we explore the potential of two different energy-restricted dietary approaches - the fibre-rich macrobiotic Ma-Pi 2 diet or a control diet recommended by Italian professional societies for T2D treatment - to correct gut microbiota dysbioses in T2D patients. In a previous 21-d open-label MADIAB trial, fifty-six overweight T2D patients were randomised to the Ma-Pi 2 or the control diet. For the present study, stools were collected before and after intervention from a subset of forty MADIAB participants, allowing us to characterise the gut microbiota by 16S rRNA sequencing and imputed metagenomics. To highlight microbiota dysbioses in T2D, the gut microbiota of thirteen normal-weight healthy controls were characterised. According to our findings, both diets were effective in modulating gut microbiome dysbioses in T2D, resulting in an increase of the ecosystem diversity and supporting the recovery of a balanced community of health-promoting SCFA producers, such as Faecalibacterium, Roseburia, Lachnospira, Bacteroides and Akkermansia. The Ma-Pi 2 diet, but not the control diet, was also effective in counteracting the increase of possible pro-inflammatory groups, such as Collinsella and Streptococcus, in the gut ecosystem, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.

Indexed as

Diet, MacrobioticMicrobiotaAdultAgedBacteriaDiabetes Mellitus, Type 2FemaleHumansIntestinesMaleMiddle AgedOverweightYoung AdultCTR control dietDysbiosisFBG fasting blood glucoseFibre-rich dietsGM gut microbiotaGut microbiotaKO KEGG OrthologyMacrobiotic dietsPCoA principal coordinates analysisT2D type 2 diabetesType 2 diabetes

Identifiers

PMID27151248
PMCPMC4894062
OpenAlexW2345810007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.