ArticleThe Journal of biological chemistry2016
Iron- and Quorum-sensing Signals Converge on Small Quorum-regulatory RNAs for Coordinated Regulation of Virulence Factors in Vibrio vulnificus.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Acetylome Analysis inPathogens (Basel, Switzerland) · 2026Article
- Article
- Review
- Characterization of quorum regulatory small RNAs in an emerging pathogenEmerging microbes & infections · 2024Article
- Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024Review
- Optimizing Conditions for the Production of Bacterial Extracellular Vesicles ofJournal of microbiology and biotechnology · 2024Article
- Proteomic analysis reveals the adaptation of Vibrio splendidus to an iron deprivation condition.Applied microbiology and biotechnology · 2023Article
- Iron-Fur complex suppresses the expression of components of the cyclo-(Phe-Pro)-signaling regulatory pathway inFrontiers in microbiology · 2023Article
- Gene Regulatory Network of the Noncoding RNAMicroorganisms · 2022Article
- MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis.Nature communications · 2022Article
- Quorum sensing and iron-dependent coordinated control of autoinducer-2 production via small RNA RyhB in Vibrio vulnificus.Scientific reports · 2022Article
- Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS).Frontiers in immunology · 2022Article
- The role of Vibrio vulnificus virulence factors and regulators in its infection-induced sepsis.Folia microbiologica · 2020Review
- Genome- and Proteome-Wide Analysis of Lysine Acetylation inFrontiers in microbiology · 2020Article
- Repression of VvpM Protease Expression by Quorum Sensing and the cAMP-cAMP Receptor Protein Complex in Vibrio vulnificus.Journal of bacteriology · 2018Article
- Role of Heat Shock Proteases in Quorum-Sensing-Mediated Regulation of Biofilm Formation bymBio · 2018Article
- Expression of Hemolysin Is Regulated Under the Collective Actions of HapR, Fur, and HlyU inFrontiers in microbiology · 2018Article
- Quorum Sensing Gene Regulation by LuxR/HapR Master Regulators in Vibrios.Journal of bacteriology · 2017Review
- Role of Non-coding Regulatory RNA in the Virulence of Human PathogenicFrontiers in microbiology · 2016Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio vulnificus is a marine bacterium that causes human infections resulting in high mortality. This pathogen harbors five quorum-regulatory RNAs (Qrr1-5) that affect the expression of pathogenicity genes by modulating the expression of the master regulator SmcR. The qrr genes are activated by phosphorylated LuxO to different degrees; qrr2 is strongly activated; qrr3 and qrr5 are moderately activated, and qrr1 and qrr4 are marginally activated and are the only two that do not respond to cell density-dependent regulation. Qrrs function redundantly to inhibit SmcR at low cell density and fully repress when all five are activated. In this study, we found that iron inhibits qrr expression in three distinct ways. First, the iron-ferric uptake regulator (Fur) complex directly binds to qrr promoter regions, inhibiting LuxO activation by competing with LuxO for cis-acting DNA elements. Second, qrr transcription is repressed by iron independently of Fur. Third, LuxO expression is repressed by iron independently of Fur. We also found that, under iron-limiting conditions, the five Qrrs functioned additively, not redundantly, to repress SmcR, suggesting that cells lacking iron enter a high cell density mode earlier and could thereby modulate expression of virulence factors sooner. This study suggests that iron and quorum sensing, along with their cognate regulatory circuits, are linked together in the coordinated expression of virulence factors.
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