ArticleParasites & vectors2016
Circumsporozoite protein rates, blood-feeding pattern and frequency of knockdown resistance mutations in Anopheles spp. in two ecological zones of Mauritania.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Malaria prevalence in Mauritania: a systematic review and meta-analysis.Malaria journal · 2023Pooled it
- Physicochemical Properties ofTropical medicine and infectious disease · 2026Article
- Changing epidemiology of Plasmodium vivax malaria in Nouakchott, Mauritania: a six-year (2015-2020) prospective study.Malaria journal · 2023Article
- Mosquito survey in Mauritania: Detection of Rift Valley fever virus and dengue virus and the determination of feeding patterns.PLoS neglected tropical diseases · 2022Article
- First report of Anopheles (Cellia) multicolor during a study of tolerance to salinity of Anopheles arabiensis larvae in Nouakchott, Mauritania.Parasites & vectors · 2020Article
- Malaria epidemiology in Kobeni department, southeastern Mauritania from 2015 to 2017.Infectious diseases of poverty · 2020Article
- Characterizing the molecular and metabolic mechanisms of insecticide resistance in Anopheles gambiae in Faranah, Guinea.Malaria journal · 2019Article
- Pyrethroid resistance in the major malaria vector Anopheles arabiensis in Nouakchott, Mauritania.Parasites & vectors · 2018Article
- Seasonal abundance, blood meal sources and insecticide susceptibility in major anopheline malaria vectors from southern Mauritania.Parasites & vectors · 2018Article
- Blood meal identification in the cryptic species Anopheles gambiae and Anopheles coluzzii using MALDI-TOF MS.Parasite (Paris, France) · 2018Article
- Mosquitoes (Diptera: Culicidae) in Mauritania: a review of their biodiversity, distribution and medical importance.Parasites & vectors · 2017Review
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11 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMosquitoes belonging to Anopheles gambiae species complex are the main malaria vector in Mauritania but data on their vector capacities, feeding habits and insecticide susceptibility are still scanty. The objectives of this study were to fill this gap.
methodsAdult Anopheles spp. mosquitoes were collected using pyrethrum spray catch method from two ecological zones of Mauritania: Nouakchott (Saharan zone) and Hodh Elgharbi region (Sahelian zone). Circumsporozoite proteins (CSP) for P. falciparum, P. vivax VK210 and P. vivax VK247 were detected by enzyme-linked immunosorbent assay (ELISA) from the female anopheline mosquitoes. To confirm CSP-ELISA results, polymerase chain reaction (PCR) was also performed. Blood meal identification was performed in all engorged females by partial sequencing of the mitochondrial cytochrome b gene. Molecular assessments of pyrethroid knockdown resistance (kdr) and insensitive acetylcholinesterase resistance (ace-1) were conducted.
resultsIn Nouakchott, the only species of Anopheles identified during the survey was Anopheles arabiensis (356 specimens). In Hodh Elgharbi, 1016 specimens of Anopheles were collected, including 578 (56.9%) Anopheles rufipes, 410 (40.35%) An. arabiensis, 20 (1.96%) An. gambiae, 5 (0.5%) An. pharoensis and 3 (0.3 %) An. funestus. Three of 186 female An. arabiensis collected in Nouakchott and tested by ELISA were found positive for Plasmodium vivax VK210, corresponding to a sporozoite rate of 1.6%; however PCR confirmed infection by P. vivax sporozoite in only one of these. In Hodh Elgharbi, no mosquito was found positive for Plasmodium spp. infection. There was a statistically significant difference in the percentage of human blood-fed Anopheles spp. between Nouakchott (58.7%, 47 of 80 blood-engorged An. arabiensis females) and Hodh Elgharbi (11.1%, 2 of 18 blood-engorged mosquitoes). Analysis of the kdr polymorphisms showed 48.2% (70/145) of East African kdr mutation (L1014S) in Nouakchott compared to 10% (4/40) in Hodh Elgharbi region (P < 0.001). Nevertheless, West African kdr mutation (L1014F) was found only in An. gambiae populations (4/40, 10%) from Hodh Elgharbi region. No ace-1 mutation was found in mosquito specimens from the two study zones.
conclusionsOverall, this study confirmed the autochthonous P. vivax malaria transmission in Nouakchott, involving An. arabiensis as the main vector. It also described for the first time the absence of ace-1 mutation, the co-occurrence of both West and East African kdr mutation in An. gambiae in Mauritania, and highlighted the regional variations in the prevalence and type of kdr mutations.
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