ArticleBMC cardiovascular disorders2016
Association of serum leptin levels with central arterial stiffness in coronary artery disease patients.
Article in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Relationship between circulating leptin levels and arterial stiffness: a systematic review and meta-analysis of observational studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Pooled it
- Weight-independent amelioration of adipokine profile by enavogliflozin, a selective SGLT2 inhibitor, in patients with type 2 diabetes.Cardiovascular diabetology · 2025Trial
- Cardiac rehabilitation may influence leptin and VEGF A crosstalk in patients after acute coronary syndrome.Scientific reports · 2022Trial
- Leptin Resistance and Cardiometabolic Disorders: Bridging Molecular Pathways, Genetic Variants, and Therapeutic Innovation.Current cardiology reviews · 2025Review
- Adipokines and Cardiometabolic Heart Failure with Preserved Ejection Fraction: A State-of-the-Art Review.Diagnostics (Basel, Switzerland) · 2024Review
- Exploring the link between leptin levels and metabolic syndrome in elderly Indian patients: Implications for family medicine and primary care practices.Journal of family medicine and primary care · 2024Article
- The Role of Carotid-Femoral Pulse Wave Velocity in a Metabolic Syndrome Patient with Sudden Cardiac Arrest: A Case Report.Healthcare (Basel, Switzerland) · 2024Article
- Associations of Three-Dimensional Anthropometric Body Surface Scanning Measurements and Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2023Article
- Clinical Study of Metabolic Parameters, Leptin and the SGLT2 Inhibitor Empagliflozin among Patients with Obesity and Type 2 Diabetes.International journal of molecular sciences · 2023Article
- Adipokines and Arterial Stiffness in Obesity.Medicina (Kaunas, Lithuania) · 2021Review
- Leptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth Muscle Cells.International journal of molecular sciences · 2021Review
- Adipokines and Subclinical Cardiovascular Disease in Post-Menopausal Women: Study of Women's Health Across the Nation.Journal of the American Heart Association · 2021Article
- Adiponectin, Leptin and Cardiovascular Disorders.Circulation research · 2021Review
- Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3-5.Adipocyte · 2020Article
- Platelet counts are associated with arterial stiffness in Chinese Han population: a longitudinal study.BMC cardiovascular disorders · 2020Article
- Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients.International journal of environmental research and public health · 2020Article
- Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients.International journal of endocrinology · 2020Article
- Role of Leptin in Cardiovascular Diseases.Frontiers in endocrinology · 2020Review
- Association of circulating BMP9 with coronary heart disease and hypertension in Chinese populations.BMC cardiovascular disorders · 2019Article
- Metabolic Syndrome With Aortic Arterial Stiffness And First Hospitalization Or Mortality In Coronary Artery Disease Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients.
methodsFasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and ≤ 10 m/s as low arterial stiffness.
resultsThirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002-1.051, P = 0.037) was a significant independent predictor of arterial stiffness.
conclusionsIncreasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.
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