ArticleThe British journal of psychiatry : the journal of mental science2016
Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis.
Open access · greenAbstract read
In one paragraph
Article in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
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- Cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD): evidence from a systematic review with meta-analysis.Translational psychiatry · 2021Pooled it
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- Differences in the Interleukin Profiles in Inattentive ADHD Prepubertal Children Are Probably Related to Conduct Disorder Comorbidity.Biomedicines · 2024Article
- Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder.International journal of molecular sciences · 2022Review
- Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD).Translational psychiatry · 2022Article
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- Biology of PEST-Containing Nuclear Protein: A Potential Molecular Target for Cancer Research.Frontiers in oncology · 2022Review
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease.International journal of molecular sciences · 2021Review
- Personalised medicine in child and Adolescent Psychiatry: Focus on omega-3 polyunsaturated fatty acids and ADHD.Brain, behavior, & immunity - health · 2021Article
- Prediction of evening fatigue severity in outpatients receiving chemotherapy: less may be more.Fatigue : biomedicine, health & behavior · 2021Article
- Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents.Translational psychiatry · 2020Article
- What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders?Frontiers in neurology · 2020Review
- Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes.Psychiatry and clinical neurosciences · 2019Article
- Transcriptional Gene Silencing of the Autism-Associated Long Noncoding RNA MSNP1AS in Human Neural Progenitor Cells.Developmental neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 7 institutions in 3 countries.
Simone de JongSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Stephen J NewhouseSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Hamel PatelSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Sanghyuck LeeSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
David DempsterSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Charles CurtisSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Jose Paya-CanoSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Declan MurphySimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
C Ellie WilsonSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Jamie HorderSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
M Andreina MendezSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Philip AshersonSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Margarita RiveraSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Helen CostelloSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Stefanos MaltezosSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Susannah WhitwellSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Mark PittsSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Charlotte TyeSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Karen L AshwoodSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Patrick BoltonSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Sarah CurranSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Peter McGuffinSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Richard DobsonSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
Gerome BreenSimone de Jong, PhD, Stephen J. Newhouse, PhD, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, MSc, Jose Paya-Cano, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Declan Murphy, MD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; C. Ellie Wilson, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain; Jamie Horder, PhD, M. Andreina Mendez, PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London; Philip Asherson, PhD, MD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Margarita Rivera, PhD, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Helen Costello, PhD, Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Stefanos Maltezos, MSc, MD, Susannah Whitwell, MD, Mark Pitts, Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK; Charlotte T
King's College London · GBCentre for Mental Health · GBMaudsley Hospital · GBBrighton and Sussex Medical School · GBSouth London and Maudsley NHS Foundation Trust · GBUniversidad de Granada · ESUniversity of Sussex · GB
Funding
Department of Health RP-PG-0606-1045Medical Research Council MR/N026063/1
Abstract
backgroundRecent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology.
aimsTo systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD).
methodAnalysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD-ASD (n = 16) and healthy controls (n = 78).
resultsWeighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures.
conclusionsOur results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.
Indexed as
Gene Expression ProfilingAdultAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderCase-Control StudiesChildFemaleGenetic Predisposition to DiseaseHumansMajor Depressive DisorderMaleMiddle AgedYoung Adult
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