Evidence map›Paper›PMID 27151065›Full record

ArticleSocial neuroscience2017

Behavioral and autonomic reactivity to moral dilemmas in frontotemporal dementia versus Alzheimer's disease.

Sylvia S Fong, Carlos David Navarrete, Sean E Perfecto, Andrew R Carr, Elvira E Jimenez, Mario F Mendez

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Social neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Vicarious Embarrassment or "Fremdscham": Overendorsement in Frontotemporal Dementia.The Journal of neuropsychiatry and clinical neurosciences · 2020
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sylvia S Fonga Department of Neurology, David Geffen School of Medicine , University of California at Los Angeles , Los Angeles , CA , USA.
Carlos David Navarretec Department of Psychology , Michigan State University , East Lansing , MI , USA.
Sean E Perfectoa Department of Neurology, David Geffen School of Medicine , University of California at Los Angeles , Los Angeles , CA , USA.
Andrew R Carrb Section of Neurology , V.A. Greater Los Angeles Healthcare Center , Los Angeles , CA , USA.
Elvira E Jimeneza Department of Neurology, David Geffen School of Medicine , University of California at Los Angeles , Los Angeles , CA , USA.
Mario F Mendeza Department of Neurology, David Geffen School of Medicine , University of California at Los Angeles , Los Angeles , CA , USA.

Funding

Early-Onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksRF1AG050967 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2016 to 2016
$1.9M
Multidisciplinary Study of Social Behavior and Emotion in Frontotemporal DementiaR01AG034499 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2009 to 2013
$1.9M
NIA NIH HHS R01 AG034499NIA NIH HHS RF1 AG050967
6 · The paper itself

Abstract

The personal/impersonal distinction of moral decision-making postulates intuitive emotional responses from medial frontal activity and rational evaluation from lateral frontal activity. This model can be analyzed in behavioral variant frontotemporal dementia (bvFTD), a disorder characterized by impaired emotional intuitions, ventromedial prefrontal cortex (vmPFC) involvement, and relative sparing of lateral frontal regions. Moral dilemmas were presented to 10 bvFTD, 11 Alzheimer's disease (AD), and 9 healthy control (HC) participants while recording skin conductance responses, a measure of emotional arousal. We evaluated their personal versus impersonal conflict, subjective discomfort, and adherence to social norms. Replicating prior work, bvFTD participants were more willing to harm in the personal, but not the impersonal, dilemma compared to AD and HC groups. BvFTD participants had lower arousal and less of an increase in conflict on the personal versus the impersonal dilemma, in contrast to increased arousal and conflict for the AD and HC groups. Furthermore, bvFTD participants verbalized less discomfort, a correlate of low adherence to social norms. These findings support impaired emotional reactions to moral dilemmas in bvFTD and vmPFC lesions and the personal/impersonal model. It suggests a reversion to utilitarian-like considerations when emotional intuition is impaired in the brain.

Indexed as

Conflict, PsychologicalMoralsAlzheimer DiseaseAnalysis of VarianceArousalAutonomic Nervous SystemDecision MakingEmotionsFemaleFrontotemporal DementiaHumansMaleMiddle AgedNeuropsychological TestsPsychophysicsRegression Analysisdementiafrontotemporal dementiamoral dilemmasMoralitysocial neuroscienceutilitarianism

Identifiers

PMID27151065
PMCPMC5651990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.